Is cell death necessary for hippocampal mossy fiber sprouting?

Epilepsy Research
J L StringerL S Dure

Abstract

To examine the relationship between cell death and sprouting of the mossy fibers, repeated seizures of the hippocampal-parahippocampal circuit were elicited in anesthetized rats. The presence of mossy fiber growth was assessed with the Timm's stain for zinc. At 4 weeks, after 18 repeated seizures, there was a significant increase in the degree of zinc containing granules in the inner molecular layer of the dentate gyrus. The amount of sprouting was less than that seen four weeks after a single injection of kainic acid. A silver impregnation stain and an assay for damaged DNA were used to detect damaged or dying neurons and immunohistochemistry for a 72 kDa heat shock protein was used to detect any neurons that had suffered potentially injurious stress. The same number of repeated seizures that caused sprouting of the mossy fibers did not cause detectable cell death or severe stress in any cells within the hippocampus, subicular region or adjacent entorhinal cortex. These experiments demonstrate that repeated seizures of the hippocampal-parahippocampal circuits can cause sprouting of mossy fibers in the absence of evidence of cell death. This supports the hypothesis that alterations in intrinsic neural excitability and impulse a...Continue Reading

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Citations

Jul 21, 2000·Hippocampus·I Cantallops, A Routtenberg
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Apr 24, 1999·The European Journal of Neuroscience·Z Q Xiong, J L Stringer
Jan 30, 1999·Epilepsia·W JiangN C de Lanerolle
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
Mar 25, 2015·Scientific Reports·Antonella Marino GammazzaAlberto J L Macario
Nov 26, 2005·The European Journal of Neuroscience·Jérôme JourquinSantiago Rivera
Jun 18, 2014·CNS Neuroscience & Therapeutics·Gergely OrbanGiuseppe Di Giovanni
Feb 8, 2018·Pharmaceuticals·José J Jarero-BasultoCarlos Beas-Zarate
Apr 29, 1998·Current Opinion in Neurology·J G Jefferys
Aug 28, 2021·International Journal of Molecular Sciences·Leila ZummoAntonella Marino Gammazza

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