Is cellular senescence an example of antagonistic pleiotropy?

Aging Cell
Stefano Giaimo, Fabrizio d'Adda di Fagagna

Abstract

It is generally accepted that the permanent arrest of cell division known as cellular senescence contributes to aging by an antagonistic pleiotropy mechanism: cellular senescence would act beneficially early in life by suppressing cancer, but detrimentally later on by causing frailty and, paradoxically, cancer. In this review, we show that there is room to rethink this common view. We propose a critical appraisal of the arguments commonly brought in support of it, and we qualitatively analyse published results that are of relevance to understand whether or not cellular senescence-associated genes really act in an antagonistic-pleiotropic manner in humans.

References

Aug 25, 1990·Nucleic Acids Research·S AraH Saya
May 31, 1990·Nature·C B HarleyC W Greider
Sep 11, 1980·Nature·M Rose, B Charlesworth
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Nov 22, 1994·Proceedings. Biological Sciences·B Charlesworth
Sep 1, 1994·Human Heredity·G BeckmanL Beckman
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Jan 1, 1996·Current Biology : CB·B Charlesworth
Dec 8, 1998·Lancet·S LanhamR Gornall
Dec 22, 1998·Nature·A HellandA L Børresen-Dale
Dec 22, 1998·Nature·A HildesheimM Carrington
Feb 13, 2001·Current Opinion in Genetics & Development·W E Wright, J W Shay
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Jan 10, 2002·Nature·Stuart D TynerLawrence A Donehower
Jul 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Thomas B L Kirkwood
Nov 12, 2002·The EMBO Journal·Isabel García-CaoManuel Serrano
Feb 5, 2003·Nature Genetics·Patrick DumontMaureen Murphy
Mar 1, 2003·Science·Paul HastyJan Vijg
May 2, 2003·Nature Reviews. Cancer·Judith Campisi
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Mar 1, 1965·Experimental Cell Research·L HAYFLICK
Nov 11, 2003·Nature·Fabrizio d'Adda di FagagnaStephen P Jackson
Nov 15, 2003·Journal of Anti-aging Medicine·Michael Fossel
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·David Pim, Lawrence Banks
Dec 4, 2003·Science of Aging Knowledge Environment : SAGE KE·Bas J Zwaan
Jan 1, 2004·The Journal of Clinical Investigation·Pier Giuseppe Pelicci
Aug 21, 2004·International Journal of Epidemiology·Sarah J Lewis, Eric J Brunner
Jan 25, 2005·Mechanisms of Ageing and Development·Armand M LeroiBas Zwaan
Mar 1, 2005·Experimental Gerontology·Diana van HeemstUNKNOWN Long Life study group
Mar 1, 2005·Cell·Thomas B L Kirkwood
Apr 20, 2005·Oncogene·Sandra L Harris, Arnold J Levine
Aug 5, 2005·Nature·Manuel ColladoManuel Serrano
Aug 5, 2005·Nature·Melanie BraigClemens A Schmitt
Aug 5, 2005·Nature·Chrysiis MichaloglouDaniel S Peeper
Jan 5, 2006·Genes & Development·Susan M MendrysaMary Ellen Perry
Jan 28, 2006·BMC Genomics·Xose S PuenteCarlos López-Otín
Mar 30, 2006·Reproductive Biomedicine Online·C B CoulamR S Jeyendran

❮ Previous
Next ❯

Citations

Jan 29, 2013·International Journal of Molecular Sciences·Xiaoman LiLiu Cao
Dec 1, 2012·Stem Cells Translational Medicine·Gary Van Zant, Ying Liang
Dec 10, 2015·Nature Medicine·Bennett G ChildsJan M van Deursen
Sep 6, 2012·Current Opinion in Cell Biology·Anthony J Cesare, Jan Karlseder
Aug 12, 2014·Current Opinion in Genetics & Development·Francesca RossielloFabrizio d'Adda di Fagagna
Sep 7, 2016·Molecular and Cellular Endocrinology·Timothy Nacarelli, Christian Sell
Oct 25, 2016·The Journal of Investigative Dermatology·Kanad Ghosh, Brian C Capell
Jan 17, 2017·Ecology Letters·Michael E Hochberg, Robert J Noble
Jul 6, 2018·Molecular Omics·Marie SaitouGunes Ekin Atilla-Gokcumen
Mar 20, 2012·Nature Cell Biology·Marzia FumagalliFabrizio d'Adda di Fagagna
Nov 28, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Edyta KawkaAchim Jörres
Apr 10, 2019·American Journal of Respiratory Cell and Molecular Biology·Shruthi HamsanathanAna L Mora
Apr 21, 2020·Frontiers in Cell and Developmental Biology·Amanpreet KaurCordula M Stover
Apr 15, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Chi Hua Sarah LinMichael S Goligorsky
Dec 2, 2020·Cells·Constanze MittermeierSusanne Muehlich
Jun 14, 2018·Cancer Prevention Research·Brian T JoyceLifang Hou
Dec 29, 2020·The Journal of Investigative Dermatology·Suzanne M PilkingtonRachel E B Watson
Nov 27, 2020·IScience·Justine BoutryFrédéric Thomas
Dec 18, 2020·Nature Reviews. Molecular Cell Biology·Raffaella Di MiccoFabrizio d'Adda di Fagagna
Jan 31, 2021·Cancers·Maria Patrizia MongiardiMaria Laura Falchetti
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Ruchi Kumari, Parmjit Jat
Aug 24, 2013·Journal of Cell Science·Jeff S PawlikowskiDavid M Nelson
Oct 29, 2018·Gerontology·Lutz HamannMonika Puzianowska-Kuznicka
May 6, 2019·Gerontology·Tamàs FülöpJacek M Witkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.