PMID: 2118440Jul 1, 1990Paper

Is central chemoreceptor sensitive to intracellular rather than extracellular pH?

Clinical Physiology
N A Lassen

Abstract

The chemosensitive area on the ventral surface of the brain stem responds to local acidosis by eliciting hyperventilation and to local alkalosis by hypoventilation. The stimulus is conventionally thought to be the hydrogen ion concentration in the area's extracellular fluid. It is pointed out, however, that the elegant studies by Loeschcke & Ahmad have demonstrated that [pH]e and [pH]i are normally tightly and rapidly coupled (Loeschcke & Ahmad, 1980). For this reason, the stimulus might just as well be the intracellular hydrogen ion concentration in the chemoreceptor area. The administration of acetazolamide allows the dissociation of [pH]e from [pH]i. With acetazolamide a sharp acid shift of CSF pH [( pH]c) is measured and in two consonance with this shift a marked increase in CBF is seen. Comparing these two reactions to that obtained with CO2 breathing, it is apparent that 7% CO2 causes about the same decrease in [pH]e and the same increase in CBF. In other words CBF acidosis can quantitatively account for the CBF increase induced by acetazolamide. But CO2 and acetazolamide influence [pH]i quite differently, as CO2 drops [pH]i to almost the same extent as [pH]c, while two recent studies by MR spectroscopy have shown that ac...Continue Reading

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Citations

Nov 1, 1993·Respiration Physiology·C E Kasserra, D R Jones
Sep 1, 1994·Respiration Physiology·J S ErlichmanJ C Leiter
Feb 1, 1994·Respiration Physiology·J S Erlichman, J C Leiter
Aug 1, 1997·Journal of the Neurological Sciences·N NighoghossianP Trouillas
Aug 8, 1998·Respiration Physiology·J VerbraeckenW De Backer
Sep 29, 1999·Progress in Neurobiology·E Nattie
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·H Kiwull-SchöneP Kiwull
Feb 1, 2003·Brain Research·Jobst Hendrik SchultzHorst Seller
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q WangN A Lassen
Sep 30, 2014·Journal of Investigative Medicine High Impact Case Reports·Javier A NeyraJames E Novak
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Oct 7, 2006·Journal of Applied Physiology·David E Leaf, David S Goldfarb
Nov 1, 1996·Journal of Applied Physiology·E E Nattie, A Li
Jun 14, 2000·Journal of Applied Physiology·I C SolomonM H O'Neal

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