Is cerebral angiography redundant in undetermined cause of stroke in patients below 50 years when the stroke is lacunar?

Journal of the Neurological Sciences
S de JongG J Luijckx

Abstract

In the diagnostic work-up of young stroke patients angiography is still considered as mandatory to identify otherwise undetected causes of stroke. We hypothesized that stroke cause is more heterogeneous among patients with a territorial infarct, whereas in lacunar stroke it is generally small vessel disease. Therefore, angiography yields more often a specific stroke cause in territorial than in lacunar infarct patients. Angiograms of 39 lacunar and 41 territorial brain infarct patients, aged between 14 and 51 years, and who had unexplained stroke cause, were evaluated. 1 of the 39 lacunar (3%), and 18 of the 41 territorial stroke patients (44%) had abnormal angiogram: odds ratio 0.03, 95% confidence interval: 0.01-0.017. The predictive value of lacunar stroke for a normal angiogram was 97%. When undetermined cause of stroke in young patients is lacunar, it is highly predictive for a normal angiogram. Our data may be of value in deciding on performing angiography in individual young stroke patients, depending on whether the stroke is territorial or lacunar.

References

May 1, 1987·Stroke; a Journal of Cerebral Circulation·J BamfordC Warlow
Aug 1, 1986·Archives of Neurology·H P AdamsG J Toffol
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·R G Hart, V T Miller
Mar 1, 1995·Annals of Internal Medicine·D D BlakeleyD B Matchar
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·J I Siqueira NetoA C Sakamoto
Sep 26, 1997·Stroke; a Journal of Cerebral Circulation·B KristensenT Olsson
Jul 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J M WardlawC P Warlow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Postgraduate Medical Journal
E L SampsonM N Rossor
Alzheimer Disease and Associated Disorders
D LeysJ Bogousslavsky
Stroke; a Journal of Cerebral Circulation
H BevanW Bradley
© 2022 Meta ULC. All rights reserved