Is Chemoradiotherapy Beneficial for Stage IV Rectal Cancer?

Oncology
Jung Wook HuhHo-Kyung Chun

Abstract

The aim of this study was to investigate the oncologic impact of preoperative or postoperative chemoradiotherapy on stage IV rectal cancer. A total of 140 consecutive patients with locally advanced mid-to-lower rectal cancer and resectable stage IV disease were prospectively enrolled. In total, 69 patients received chemoradiotherapy (26 preoperatively and 43 postoperatively); in contrast, 71 did not. Survival curves were constructed using the Kaplan-Meier method, and a multivariate analysis was performed to identify independent prognostic factors. According to the multivariate analysis, radiation therapy was not an independent factor associated with either survival or recurrence. The overall survival curves revealed that patients who underwent radiotherapy tended to have a better survival compared with patients who did not undergo radiotherapy; however, this trend was not statistically significant (p = 0.057). The disease-free, local recurrence-free, and distant metastasis-free survival curves did not differ significantly between the two groups. The local recurrence-free survival rates for patients who underwent preoperative radiotherapy were significantly higher than those for patients who underwent postoperative radiotherapy ...Continue Reading

Citations

Oct 26, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·K T LiuZ Zhang
Oct 27, 2017·World Journal of Clinical Oncology·Hiroshi TamuraToshifumi Wakai
Jul 26, 2018·Journal of Gastrointestinal Cancer·Ryan Anthony F AgasTeresa T Sy Ortin
Jan 26, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Pamela MilitoMaurizio Cosimelli

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