Is cholesterol a mediator of cold-induced cancer?

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chandi C MandalJames A Radosevich

Abstract

Many factors such as smoking, obesity, and high fat have been either directly or indirectly linked to cancer deaths and/or incidences. Similarly, abnormal serum cholesterol levels have been assigned as a risk factor for cancer, but some studies show a discrepant result. To resolve this discrepancy, we have analyzed cholesterol data of 166 countries. Univariate analysis showed a positive correlation between serum average total cholesterol (ATC) and overall cancer mortality rate (CMR) [tau = 0.277, z = 5.19, p < 0.0001]. It was also observed that a similar positive correlation was found between ATC and different anatomical site-specific CMRs in lung, bladder, ovarian, breast, and pancreatic cancers. Our recent published data documented an existence of a negative correlation between average annual temperature (AAT) and overall CMR, as well as CMR of the abovementioned anatomical site-specific cancers. Statistical analysis further shows a negative correlation between AAT and ATC, similar to that of AAT and CMR. The resulting patterns of univariate analysis between AAT and CMR are almost identical with AAT and ATC, when this analysis was performed every 2 °C of AAT increment for all countries. Moreover, geographical location of the ...Continue Reading

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Citations

Oct 13, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ankit SharmaChandi C Mandal
Sep 21, 2017·Frontiers in Pharmacology·Kaushik ChowdhuryChandi C Mandal
Aug 11, 2020·Expert Review of Anticancer Therapy·Chandi C Mandal
Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Shreetama BandyopadhayayaChandi C Mandal
Jun 15, 2019·Cell Calcium·Sana KoubaMarie Potier-Cartereau

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