Is chorionic villus sampling associated with hypertensive disorders of pregnancy?

Prenatal Diagnosis
Anthony O OdiboJames Crane

Abstract

Our objective is to evaluate for potential associations between chorionic villus sampling (CVS) and hypertensive disorders of pregnancy. Using our genetic database, we compared the rates of hypertensive disorders between women who underwent CVS at 10-13 and 6/7 weeks with those seen for other indications at similar gestational ages who had no invasive procedure. Only singleton and euploid pregnancies were included. Statistical methods including univariable and multivariable logistic regression, supplemented by stratified analyses were used for comparisons. Among 11 012 pregnant women seen between 1990 and 2006 in our center and meeting the inclusion criteria, information on hypertensive disorders of pregnancy were available in 9386, and 9098 met the inclusion criteria. The overall incidence of hypertensive disorders was 421/9098 (4.6%), with 138/5096 (2.7%) in the CVS group and 283/4002 (7.1%) in the control group [adjusted odds ratio (adjOR) 0.47, 95% confidence interval (CI), 0.38-0.59]. Similar findings were seen on stratified analyses for gestational age of procedure and the type or severity of hypertensive disorder, and other potential confounders. The rate of hypertensive disorders of pregnancy is significantly lower in w...Continue Reading

References

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Oct 2, 2008·Obstetrics and Gynecology·Anthony O OdiboJames P Crane
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Citations

Oct 11, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kyle J RehderIra M Cheifetz
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Apr 30, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zeynep SoymanMelahat Atasever
Jun 16, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Yoko KawanishiHiroomi Okuyama
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Jan 25, 2011·Archives of Gynecology and Obstetrics·Ahmet BasaranBetül Topatan

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