Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury?

Annals of Surgery
J L KellyM L Rodrick

Abstract

Patients with severe traumatic or burn injury and a mouse model of burn injury were studied early after injury to determine the relation of plasma endotoxin (lipopolysaccharide [LPS]) to the production of proinflammatory cytokines and subsequent resistance to infection. Elevated levels of plasma LPS have been reported in patients after serious injury. It has been suggested that circulating LPS may be a trigger for increased proinflammatory cytokine production and may play a role in the septic syndromes seen in a substantial portion of such patients. Yet, despite multiple reports of leakage of LPS from the gut and bacterial translocation after injury in animal models, there is little direct evidence linking circulating LPS with production of inflammatory mediators. The authors studied serial samples of peripheral blood from 10 patients with 25% to 50% surface area burns and 8 trauma patients (injury Severity Score, 25-57). Patients were compared with 18 healthy volunteers. The study was focused on the first 10 days after injury before the onset of sepsis or the systemic inflammatory response syndrome. Plasma samples were assayed for LPS, and adherent cells from the blood were studied for basal and LPS-stimulated production of tu...Continue Reading

References

Nov 1, 1992·Journal of Clinical Immunology·M L RodrickI B Saporoschetz
Dec 23, 1992·JAMA : the Journal of the American Medical Association·R C Bone
Feb 1, 1992·Archives of Surgery·M G O'RiordainM L Rodrick
Jul 1, 1989·The Journal of Trauma·F A MooreV M Peterson
Jul 1, 1994·The Journal of Surgical Research·M H LiM A West
Sep 1, 1993·Annals of Surgery·A M MunsterR A Winchurch
Jun 1, 1993·Critical Care Medicine·R C HochE Abraham

❮ Previous
Next ❯

Citations

Oct 24, 2007·Pediatric Surgery International·Georg SingerD Neil Granger
Mar 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Clare E McNaughtJohn MacFie
Mar 20, 1999·Transplantation Proceedings·L CicaleseT E Starzl
Sep 11, 2001·Journal of the American College of Surgeons·J A MannickJ A Lederer
Feb 8, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·N Ni Choileain, H P Redmond
Jun 11, 1999·Annals of Surgery·K FukuzukaD W Mozingo
Feb 6, 2004·Critical Care Medicine·Kevin C DoerschugGary W Hunninghake
Jul 11, 2009·The Journal of Trauma·J Jason HothCharles E McCall
Jul 20, 2004·Clinical Microbiology Reviews·Ian A ClarkWilliam B Cowden
Dec 8, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D BastianO Reikerås
Jul 1, 2009·Critical Care : the Official Journal of the Critical Care Forum·Franco ValenzaLuciano Gattinoni
Oct 12, 2010·Critical Care : the Official Journal of the Critical Care Forum·Beatrice HaimovichStephen F Lowry
Jul 12, 2013·PloS One·Fangming XiuMarc G Jeschke
Mar 3, 2001·Sports Medicine·A I MoldoveanuP N Shek
Feb 4, 2016·European Journal of Sport Science·Jenna SessionsMicah Zuhl
Jun 10, 2008·Burns : Journal of the International Society for Burn Injuries·G C BloemsmaI M M H Oen
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katsuyoshi HabiroRyo Abe
Nov 22, 2005·Trends in Molecular Medicine·Gregory J Brunn, Jeffrey L Platt
Apr 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·S WanJ L Vincent
Oct 19, 2000·The Journal of Trauma·K FukuzukaD W Mozingo
Oct 22, 2004·Journal of Leukocyte Biology·Thomas J MurphyJames A Lederer
Jun 28, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D BastianO Reikerås
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Sanjukta ChakrabortyMariappan Muthuchamy
May 18, 2020·Antioxidants·Manuele GoriMichele Pier Luca Guarino
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·I T Campbell
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hugh M PatersonJames A Lederer
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zoltán H NémethGyörgy Haskó
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·James A ThomasJureta W Horton
Oct 30, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H FreiseH U Spiegel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.