Is cognitive stability in Parkinson's disease a predictable phenomenon? A 5-year follow-up study

Journal of Neural Transmission
Maria Elena Di BattistaG Meco

Abstract

Cognitive disturbances are integral to the course of PD but the rate of cognitive decline remains largely unpredictable. The aim of this study was to determine the clinical features associated with "cognitive stability". Fifty-four patients (32 with normal cognition and 22 featuring MCI) were recruited in 2009 and re-evaluated after a mean time of 4.7 years; all patients underwent a detailed neuropsychological and clinical evaluation. A proportion of 61 % of patients (19 with normal cognition and 14 with MCI) remained cognitive stable, whereas 39 % had reduced cognitive reserve. After multivariate analysis, only the preservation of visuo-spatial domain was predictive of cognitive stability.

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Oct 9, 2009·Brain : a Journal of Neurology·Caroline H Williams-GrayRoger A Barker
Apr 7, 2011·The Clinical Neuropsychologist·Matthew CalamiaDaniel Tranel
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Apr 10, 2012·Neurobiology of Disease·Javier Pagonabarraga, Jaime Kulisevsky
Nov 30, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Michele PolettiUbaldo Bonuccelli
Mar 8, 2013·Practical Neurology·David J Burn, Roger A Barker
Mar 20, 2013·Journal of Neural Transmission·Amos D Korczyn
Aug 31, 2014·Neurology·Julius B M AnangRonald B Postuma

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