Is conception delay a risk factor for reduced gestation or birthweight?

Paediatric and Perinatal Epidemiology
Maureen A CooneyMark A Klebanoff

Abstract

Previous studies have suggested an association between delays in conception and adverse perinatal outcomes, specifically, low birthweight and preterm birth. We investigated the relationship between conception delay (defined as >6 months to become pregnant) and three perinatal outcomes: low birthweight (LBW; <2500 g), preterm birth (PTB; <37 weeks), and small-for-gestational-age (SGA; <10th percentile weight for given gestational age) using data from the Collaborative Perinatal Project. The study cohort was limited to pregnancies with a known time-to-pregnancy (n = 8465; 15%). Generalised estimating equations were used to estimate odds ratios (OR) and 95% confidence intervals [CI] for risk of adverse perinatal outcomes accounting for the clustering of pregnancy outcomes for women with more than one pregnancy. After adjusting for confounders, all ORs were close to the null (LBW, OR = 1.01; 95% CI = 0.86, 1.20), (PTB, OR = 1.10; 95% CI = 0.95, 1.27), (SGA, OR = 1.06; 95% CI = 0.91, 1.25). Thus, we found no evidence to support an adverse relationship between conception delay and decrements in gestation or birthweight among this select sample of fertile women, even after varying the cut-point for defining conception delay.

References

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Citations

Dec 7, 2007·Obstetrics and Gynecology·Jin Liang ZhuOlga Basso
Dec 17, 2009·Fertility and Sterility·Kaisa RaatikainenSeppo Heinonen
Nov 13, 2008·Paediatric and Perinatal Epidemiology·Lisa M Bodnar, Hyagriv N Simhan
Jun 14, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Sonia ChaabaneAnick Bérard
Sep 27, 2006·Human Reproduction·R M FerrariG M Buck Louis

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