PMID: 8611603Jan 12, 1996Paper

Is control of distribution of liposomes between tumors and bone marrow possible?

Biochimica Et Biophysica Acta
A NagayasuH Kiwada

Abstract

The objective of this study is to clarify to what extent the accumulation of liposomes from the blood into the tumor and bone marrow can be controlled by liposome size and membrane fluidity. Liposomes with different diameters (50-400 nm) and different membrane fluidity were prepared from hydrogenated egg phosphatidylcholine (HEPC) or egg phosphatidylcholine (EPC), cholesterol (Ch) and dicetylphosphate in various molar ratios. These liposomes were injected intravenously into rats bearing Yoshida sarcoma, and the ratios of the accumulation of liposomes in the tumor to those in the bone marrow, liver and spleen were compared. The tumor-to-bone marrow accumulation ratio increased with the decrease in liposome size from 400 to 50 nm. This ratio was greater than those for the liver and spleen at all sizes. Although tumor-to-liver accumulation ratios of 50- and 100-nm HEPC-containing liposomes were higher than those of EPC-containing liposomes, no obvious difference in tumor-to-bone marrow or tumor-to-spleen accumulation ratios was found between these liposomes. Tumor-to-bone marrow accumulation ratio of HEPC-containing liposomes increased remarkably with the decrease in Ch content from 40 to 30 or 20 mol% compared with ratios for the...Continue Reading

References

Jun 29, 1992·Biochimica Et Biophysica Acta·S M Moghimi, H M Patel
Sep 18, 1989·Biochimica Et Biophysica Acta·S M Moghimi, H M Patel
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Gabizon, D Papahadjopoulos
Mar 1, 1994·Pharmaceutical Research·K FunatoH Kiwada

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Citations

Sep 23, 2000·International Journal of Pharmaceutics·T IshidaH Kiwada
Jun 28, 2002·International Journal of Pharmaceutics·Crispin R Dass
Aug 23, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tetsuya WatanabeYoshinobu Fukumori
Jan 16, 2016·International Journal of Pharmaceutics·M A CollierK M Ainslie
Nov 22, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kuan-Boone TanGigi N C Chiu
Oct 26, 2011·International Journal of Pharmaceutics·Kouichi ShiraishiMasayuki Yokoyama
Oct 21, 2011·Journal of Liposome Research·Ana Paula Landi-LibrandiYara Maria Lucisano-Valim
Feb 7, 2002·The Journal of Pharmacy and Pharmacology·Crispin R Dass
Aug 21, 2013·The Journal of Antimicrobial Chemotherapy·Kevin J PeineEric M Bachelder
Jan 1, 1996·Drug Delivery·T L Whateley

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