Is coronary heart disease caused by an environmentally-induced chronic metabolic imbalance?

Medical Hypotheses
D P StGeorge

Abstract

The hypothesis is put forward that coronary heart disease (CHD) arises from a chronic imbalance between anabolism and catabolism in the body, induced by the psychosocial environment and mediated through the central nervous system (CNS) and neuroendocrine system. Psychosocial demands increase periods of waking arousal and reduce the periods of rest necessary to compensate for the catabolic and degradative effects of activity. This prevents the complete healing of repeated arterial damage caused by haemodynamic stress, and enhances the accumulation of lipids into damaged areas in the arterial wall. This hypothesis can account for the significance of known CHD risk factors. A high-fat diet exacerbates the problem by increasing the rate of lipid accumulation into the arterial lesions. Cigarette smoking increases CHD risk by acting as a stimulant of the arousal-inducing neuroendocrine mechanisms, and moderate alcohol consumption reduces CHD risk by depressing CNS arousal. Physical activity enforces subsequent inactivity and compensatory anabolism through feedback mechanisms, which "overshoots" and produces a net anabolic effect that increases cardiovascular strength and general resistance to physical strain.

References

Jun 1, 1979·Journal of Epidemiology and Community Health·E Guberan
Dec 1, 1979·Journal of the American Dietetic Association
Dec 1, 1978·Journal of Epidemiology and Community Health·M G MarmotP J Hamilton
Jan 1, 1975·International Journal of Health Services : Planning, Administration, Evaluation·J Eyer
Mar 14, 1981·Lancet·M G MarmotB J Thomas
Apr 17, 1982·British Medical Journal·J L DayC N Simpson
Jul 19, 1980·British Medical Journal·B Lewis
Oct 1, 1980·British Journal of Diseases of the Chest·R Stepney
Feb 1, 1981·Social Science & Medicine. Part E, Medical Psychology·P Sterling, J Eyer
Dec 17, 1981·The New England Journal of Medicine·R A Bruce
Jun 27, 1980·Science·R M NeremJ F Cornhill
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E Bünning, I Moser

❮ Previous
Next ❯

Citations

Jan 1, 1987·Medical Hypotheses·A Yabrov
Jul 1, 1987·The Journal of Peasant Studies·E Croll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.