Is cortisol a modulator of interferon tau action in the endometrium during early pregnancy in cattle?

Journal of Reproductive Immunology
Magdalena MajewskaDariusz J Skarzynski

Abstract

Glucocorticoids (GCs) were recently found to be potent modulators of the secretion of uterine prostaglandins (PGs) in ruminants. The aim of the present study was to examine whether GCs may serve as a mediator/modulator of interferon-τ (IFNT) action during early pregnancy in cows. We examined whether IFNT affects cortisol output and expression of GC receptors (NR3C1) and 11β-hydroxysteroid dehydrogenases (enzymes responsible for GC conversion: HSD11B1 and HSD11B2) in bovine endometrium. Endometrial tissues were collected from cyclic and pregnant cows on Days 16-17. Endometrial stromal and epithelial cells were isolated from uteri from cyclic cows in the early luteal phase (Days 2-5). The mRNA and protein expressions of NR3C1, HSD11Bs in endometrial strips and cultured cells were analyzed. Endometrial slices and isolated cells were incubated with cortisone in the presence or absence of IFNT and HSD11B1 activity was evaluated. IFNT increased HSD11B1 activity in endometrial strips and both types of endometrial cells. IFNT influenced NR3C1 and HSD11Bs mRNA and protein expression in epithelial and stromal cells. Expressions of HSD11Bs and NR3C1 mRNA and protein in bovine endometrium were different on Days 16-17 of the estrous cycle c...Continue Reading

References

Apr 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·F W Bazer
Sep 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D W Brann, V B Mahesh
May 1, 1988·Journal of Reproduction and Fertility·M A FortierF Grasso
Aug 29, 1986·Cell·V GiguèreR M Evans
Jan 1, 1995·Steroids·P M Stewart, J I Mason
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Oct 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M Goppelt-StruebeM Grell
Jul 21, 1997·The Journal of Experimental Medicine·G EscherF J Frey
Nov 5, 1997·Molecular and Cellular Endocrinology·E AsselinM A Fortier
Oct 24, 1998·Journal of Reproductive Immunology·S G Hillier, M Tetsuka
Apr 30, 1999·Physiological Reviews·J A McCrackenJ C Lamsa
Mar 4, 2003·Prostaglandins & Other Lipid Mediators·J KotwicaR Rekawiecki
Mar 8, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·E T KorgunT Hahn
Apr 18, 2003·Journal of the Society for Gynecologic Investigation·Shalini GuptaJohn R G Challis
Oct 4, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Anthony E MichaelMichael T Rae
Feb 18, 2004·The Journal of Reproduction and Development·Shuko MurakamiKiyoshi Okuda
Jul 24, 2004·Animal Reproduction Science·G Jenkin, I R Young
Jan 26, 2008·Biology of Reproduction·Junichi KomiyamaKiyoshi Okuda
Oct 1, 2008·The Journal of Endocrinology·Michiyo TanikawaKiyoshi Okuda
May 1, 2009·The Journal of Reproduction and Development·Izabela Woclawek-PotockaDariusz J Skarzynski
Nov 30, 2010·Reproductive Biology·Marta J SiemieniuchDariusz J Skarżyński

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Citations

Sep 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·A Vitorino CarvalhoO Sandra
Apr 13, 2019·Biology of Reproduction·José María SánchezPat Lonergan
Jul 20, 2013·American Journal of Public Health·Jenine K HarrisDoneisha Snider
Jan 11, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·A N AmwegH H Ortega
Nov 24, 2019·Reproductive Biology and Endocrinology : RB&E·Junsheng DongHeng Wang
Aug 13, 2020·Animals : an Open Access Journal From MDPI·Jordana S LopesPilar Coy
Nov 25, 2020·Animals : an Open Access Journal From MDPI·Mateo Ruiz-ConcaManuel Alvarez-Rodriguez

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