Is cough really necessary for TB transmission?

Tuberculosis
Benjamin Patterson, Robin Wood

Abstract

Cough has long been implicated in the production of infectious aerosol leading to transmission of tuberculosis (TB). However, prevalence studies frequently identify radiographic evidence of TB in subclinical individuals in the absence of reported coughing. Elucidating the role of cough in transmission depends on understanding the physical process of aerosolizing and expelling mycobacterium tuberculosis (Mtb) bacilli. In the last decade, human aerosol studies have progressed with improved precision of particle detection and greater sophistication of experimental protocols. Combining principles of respiratory physiology, the site and mechanism of aerosolization of respiratory lining fluids during phases of the respiratory cycle has been investigated in detail. Additionally, recent success in the direct detection of naturally generated Mtb aerosols has allowed more detailed characterization in terms of their rate of production and size distribution. We propose that TB transmission depends on the coincidence of the site of aerosol generation with the presence of Mtb bacilli. This review will examine the evidence for site of aerosol production during cough and respiratory activities in conjunction with the characteristics of detecta...Continue Reading

Citations

Apr 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tara C Bouton, Karen R Jacobson
Aug 11, 2020·BMC Infectious Diseases·Benjamin PattersonRobin Wood
Nov 17, 2020·American Journal of Respiratory and Critical Care Medicine·Emily A KendallDavid W Dowdy
Jul 28, 2020·The Lancet. Respiratory Medicine·Kevin P Fennelly
Dec 15, 2020·Tuberculosis·Benjamin PattersonRobin Wood
Dec 17, 2020·Tropical Medicine and Infectious Disease·Lan Huu NguyenNhung Viet Nguyen
Sep 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatrice FrascellaRein M G J Houben
Aug 28, 2021·Science·Chia C WangLinsey C Marr

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BETA
PCR
lavage

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Scopus

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