Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

Thrombosis Research
Alexander Fletcher-Sandersjöö, Bo-Michael Bellander


Severe acute respiratory syndrome coronavirus 2 is responsible for the current COVID-19 pandemic resulting in an escalating number of cases and fatalities worldwide. Preliminary evidence from these patients, as well as past coronavirus epidemics, indicates that those infected suffer from disproportionate complement activation as well as excessive coagulation, leading to thrombotic complications and poor outcome. In non-coronavirus cohorts, evidence has accumulated of an interaction between the complement and coagulation systems, with one amplifying activation of the other. A pressing question is therefore if COVID-19 associated thrombosis could be caused by overactivation of the complement cascade? In this review, we summarize the literature on thrombotic complications in COVID-19, complement activation in coronavirus infections, and the crosstalk between the complement and coagulation systems. We demonstrate how the complement system is able to activate the coagulation cascade and platelets, inhibit fibrinolysis and stimulate endothelial cells. We also describe how these interactions see clinical relevance in several disorders where overactive complement results in a prothrombotic clinical presentation, and how it could be cli...Continue Reading


Sep 19, 1979·The Journal of Experimental Medicine·M J Polley, R L Nachman
Jun 1, 1978·The Journal of Experimental Medicine·M J Polley, R Nachman
Jun 1, 1984·The Journal of Clinical Investigation·A de AgostiniM Schapira
Sep 1, 1994·The Journal of Clinical Investigation·K E ForemanP A Ward
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M CugnoA Agostoni
Feb 20, 2002·Trends in Biochemical Sciences·Maxwell M Krem, Enrico Di Cera
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E W BrownP A Patston
Oct 30, 2004·Drug News & Perspectives·Alvin E Davis
May 23, 2006·Nature Medicine·Markus Huber-LangPeter A Ward
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Konstantinos RitisJohn D Lambris
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Nidhi MehtaAmy H Kao
Mar 18, 2009·Journal of Thrombosis and Haemostasis : JTH·F C GushikenV Afshar-Kharghan
Sep 15, 2010·Cell and Tissue Research·J Vidya Sarma, Peter A Ward
Sep 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Umme AmaraMarkus Huber-Lang
Jun 19, 2013·Seminars in Immunology·Markus Huber-LangAnita Ignatius
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Apr 15, 2016·EBioMedicine·Jonathan H FoleyEdward M Conway
Apr 30, 2016·Circulation Research·Jonathan H Foley, Edward M Conway
May 9, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·John ChapinJeffrey Laurence
Jun 30, 2016·Shock·Gelareh AtefiGeorge C Tsokos
Mar 2, 2017·The Journal of Clinical Investigation·Vahid Afshar-Kharghan
Jun 20, 2017·Hematology Reports·Kuixing ZhangMinh-Ha Tran
Feb 21, 2018·Shock·Martijn van GriensvenMarkus Huber-Lang
Mar 7, 2018·Nature Immunology·Markus Huber-LangPeter A Ward
Apr 25, 2018·Emerging Microbes & Infections·Yuting JiangYusen Zhou
Dec 7, 2018·Hematology·Samuel A Merrill, Robert A Brodsky
Jun 7, 2019·Lupus Science & Medicine·Michelle A PetriThierry Dervieux
Nov 2, 2019·Transfusion Medicine Reviews·Sunny Dzik
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 1, 2020·International Journal of Molecular Sciences·Alexander Fletcher-SandersjööBo-Michael Bellander
Apr 18, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Cynthia MagroJeffrey Laurence

❮ Previous
Next ❯


Oct 4, 2020·Pediatric Blood & Cancer·Chrysoula KosmeriAlexandros Makis
Sep 28, 2020·Molecular Neurobiology·Hamid Soltani ZangbarTahereh Ghadiri
Oct 11, 2020·The Journal of Infectious Diseases·Aline H de NooijerUNKNOWN RCI-COVID-19 study group
Nov 5, 2020·Cells·Mohamed Hassan KamelVipul C Chitalia
Jan 11, 2021·Vascular Pharmacology·Lucas Cunha BarbosaValéria Pereira Ferrer
Jan 26, 2021·Thrombosis Research·Eden M Page, Robert A S Ariëns
Feb 3, 2021·International Journal of Molecular Sciences·Hau C Kwaan, Paul F Lindholm
Jan 23, 2021·European Journal of Pharmacology·Parastoo TarighiParastoo Mirzabeigi
Feb 16, 2021·Academic Radiology·K M CapaccioneM M Salvatore
Mar 7, 2021·Tropical Medicine and Infectious Disease·Sabina KarimIsmail Laher
Mar 11, 2021·Pharmacological Reviews·Peter GarredTom E Mollnes
Mar 12, 2021·Frontiers in Molecular Biosciences·Elettra BarberisMarcello Manfredi
Mar 20, 2021·Molecular and Cellular Biochemistry·Maria Luiza Mukai FranciosiAndréia Machado Cardoso
Apr 1, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Carlos A CañasFabio Bonilla-Abadía
Apr 3, 2021·Thrombosis Research·S BarcoF A Klok
Apr 6, 2021·Current Opinion in Toxicology·Ayse Basak EnginAtilla Engin
Apr 16, 2021·Frontiers in Cardiovascular Medicine·Saeideh Aghayari Sheikh NeshinRamin Zand
Jun 1, 2021·Frontiers in Immunology·Esther J NossentTom van der Poll
Jun 3, 2021·Journal of Clinical Medicine·Nicole Ng, Charles A Powell
Jul 6, 2021·Cellular and Molecular Bioengineering·Elisabeth SteadmanWei Yin
Aug 6, 2021·SAGE Open Medical Case Reports·Raíssa Lanna Araújo San MartinRogério da Hora Passos
Jul 25, 2021·BMJ Case Reports·Sam MyersSaurabh Jain

❮ Previous
Next ❯

Methods Mentioned

flow cytometry

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Cleveland Clinic Journal of Medicine
Alfred H J KimJohn P Atkinson
European Journal of Immunology
Nassima Chouaki BenmansourEric Vivier
Critical Reviews in Clinical Laboratory Sciences
Maria Alice V WillrichAshley Frazer-Abel
© 2021 Meta ULC. All rights reserved