PMID: 8957335Sep 1, 1996Paper

Is cytokine expression responsible for differences between allergens and irritants?

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
G MüllerA H Enk

Abstract

Irritant and allergic contact dermatitis are two very similar diseases, and differentiating between these two can be difficult clinically. Recently, cytokines have been identified as useful tools for differentiation. Thus, our laboratory has identified an early cytokine pattern in the induction phase of contact sensitivity that is specific for allergens and is not found after epicutaneous application of irritants or tolerogens. The up-regulation of the Langerhans' cell-derived signal interleukin (IL)-1 beta early after allergen application especially seems to be highly specific for contact allergens. This cytokine was also found to be essential for the development of epicutaneous sensitization because injection of an anti-IL-1 beta monoclonal antibody before epicutaneous application of an allergen prevented sensitization. Additionally, cytokines also seem to be involved in down-modulating an ongoing inflammatory reaction such as contact sensitivity. IL-10 especially was shown to inhibit the LC accessory functions and to down-modulate inflammatory cytokines. The homeostasis of proinflammatory and counterregulatory cytokines and their clinical implications are discussed in this review.

References

Aug 1, 1976·Cellular Immunology·I Silberberg-SinakinV Berezowsky
Jan 26, 1991·Lancet·J N BarkerB J Nickoloff
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Feb 1, 1991·Current Opinion in Immunology·B Sherry, A Cerami
Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S D WolpeA Cerami
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C Hauser, S I Katz
Aug 1, 1988·The Journal of Experimental Medicine·R Fernandez-BotranE S Vitetta
Mar 1, 1985·The Journal of Experimental Medicine·G Schuler, R M Steinman
Nov 1, 1994·The Journal of Clinical Investigation·G MüllerA H Enk
Jul 1, 1994·The Journal of Experimental Medicine·N RomaniG Schuler
Apr 1, 1994·The Journal of Experimental Medicine·A H EnkJ Knop
Sep 1, 1993·The Journal of Experimental Medicine·C HeuflerG Schuler
Jan 1, 1957·International Archives of Allergy and Applied Immunology·J R FREY, P WENK

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Citations

Feb 10, 2000·Toxicology·E Corsini, C L Galli
Jul 12, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E CorsiniC L Galli
Mar 16, 2011·Critical Reviews in Toxicology·Jonathan BorakMark A Pemberton

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