Is D-dimer helpful in evaluating stroke patients? A systematic review

Acta Neurologica Scandinavica
E Haapaniemi, Turgut Tatlisumak

Abstract

D-dimer (DD) is a fibrin degradation product present in negligible amounts in healthy individuals, but in thrombotic/fibrinolytic conditions substantially increases in plasma. Over the last two decades numerous studies have explored whether DD measurements would help stroke clinicians. An easy, reliable, and inexpensive test for stroke diagnosis, determination of stroke subtype, severity, prognosis, and recurrence risk is being sought. We searched the database, of studies indexed in English on MEDLINE, using the keywords 'cerebral venous thrombosis, D-dimer, deep vein thrombosis, intracerebral hemorrhage, ischemic stroke, outcome, prognosis, and subarachnoid hemorrhage' for relevant studies. Here, we systematically review current evidence on plasma DD levels in patients with ischemic and hemorrhagic strokes, transient ischemic attacks, and cerebral venous thrombosis. Numerous studies showed that patients with various strokes and stroke-related diseases had acutely increased plasma DD levels. Plasma DD levels, however, are neither sensitive nor specific enough to be utilized in stroke diagnostics and cannot replace either clinical or radiological evaluation. Regarding prediction of patient outcome, good clinical evaluation is cl...Continue Reading

References

Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·K TakanoK Uchida
Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·N OnoE Kakishita
Jan 1, 1991·Stroke; a Journal of Cerebral Circulation·K TakanoT Omae
Dec 1, 1990·Stroke; a Journal of Cerebral Circulation·H TohgiH Suzuki
May 1, 1989·Stroke; a Journal of Cerebral Circulation·W M FeinbergJ J Corrigan
Mar 1, 1987·Human Pathology·C W Francis, V J Marder
Jun 27, 1983·Annals of the New York Academy of Sciences·V J Marder, C W Francis
Aug 1, 1995·Neurosurgery·Y FujiiR Tanaka
Sep 1, 1995·Clinical Science·G Y Lip, G D Lowe
Oct 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M YamazakiS Maruyama
Jan 1, 1995·Acta Haematologica·A AltèsJ Fontcuberta
Sep 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·J W van Wersch, C L Franke
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·H TohgiK Tamura
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·W M FeinbergJ Kittelson
Feb 1, 1997·Stroke; a Journal of Cerebral Circulation·M M KaarisaloJ Tuomilehto
Aug 1, 1997·Journal of Neurosurgery·S PeltonenR Lassila
Jul 1, 1997·QJM : Monthly Journal of the Association of Physicians·H BounameauxM J Miron
Jan 24, 1998·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·J E WildbergerD Vorwerk
Apr 8, 1998·British Journal of Haematology·F B SmithG D Lowe
Dec 8, 1998·American Heart Journal·V RoldánF Sogorb
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·D A QuinnC A Hales
Dec 10, 1999·Thrombosis Research·B InceT Ulutin
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C F PieperH J Cohen
Dec 2, 2000·Journal of the Neurological Sciences·S KataokaT Saigan
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·Y FujiiR Tanaka
May 9, 2001·Thrombosis Research·E BergeP M Sandset
Sep 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M E HoffmannG Gaddis
Apr 11, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·F CouturaudJ S Ginsberg
Apr 17, 2002·Circulation·S Goya WannametheeLucy Lennon
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Mario Di NapoliUNKNOWN Villa Pini Stroke Data Bank Investigators
Sep 5, 2002·The American Journal of Medicine·Bernard TardyChristophe Venet
Dec 3, 2002·Archives of Internal Medicine·Walter AgenoAchille Venco
Jan 21, 2003·Journal of Neurology·Kevin TalbotDavid Keeling
Apr 24, 2003·Seminars in Thrombosis and Hemostasis·Margareta Hellgren
Jul 2, 2003·Emergency Medicine Journal : EMJ·A WakaiD Winter
Sep 26, 2003·The New England Journal of Medicine·Philip S WellsMichael J Kovacs

❮ Previous
Next ❯

Citations

Feb 18, 2010·Biomarkers in Medicine·Matthew B Maas, Karen L Furie
Mar 16, 2013·Journal of Emergencies, Trauma, and Shock·Youichi YanagawaRyota Tanaka
Feb 9, 2010·Expert Review of Neurotherapeutics·Nada El Husseini, Daniel T Laskowitz
Feb 11, 2011·Expert Review of Neurotherapeutics·Mira Katan, Mitchell S V Elkind
Jan 15, 2014·Expert Review of Neurotherapeutics·Yanying Miao, James K Liao
Oct 24, 2012·Journal of the Chinese Medical Association : JCMA·Ping-Tsun LaiHung-Yi Hsu
Feb 26, 2013·Journal of the Neurological Sciences·Sini HiltunenTurgut Tatlisumak
Dec 18, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·G Guenther, A Arauz
Jul 14, 2010·Ultrasound in Medicine & Biology·David SkoloudíkRoman Herzig
Dec 1, 2009·Emergency Medicine Clinics of North America·Stuart P Swadron
Aug 24, 2010·Acta Neurologica Scandinavica·L-H KrarupEivind Berge
Nov 28, 2012·Health Information and Libraries Journal·Trish Chatterley, Liz Dennett
Mar 28, 2012·Annals of Neurology·Dawn N Kernagis, Daniel T Laskowitz
Sep 29, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Andrea ElliottJames C Grotta
Jan 28, 2010·The American Journal of Medicine·Jecko ThachilCheng Hock Toh
Mar 19, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xin HuMing Liu
Nov 5, 2011·Journal of Korean Neurosurgical Society·Young-Woo ParkHa-Young Choi
Sep 30, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tae-Won KimSung-Woo Chung
Mar 24, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sinan CerşitMehmet Özkan
Jan 27, 2018·Journal of Neurology·Tomohisa NezuYoshiki Yagita
Mar 5, 2019·Neuromolecular Medicine·Joseph Kamtchum-Tatuene, Glen C Jickling
Mar 21, 2018·Current Hypertension Reports·Stephen Boone, Dick Kuo
Sep 21, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Tomoyuki OharaAndrew M Demchuk
Sep 1, 2017·BMC Cancer·Jeong-Am RyuGeun-Ho Lee
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Kristina JohanssonMarcus Lind
Aug 27, 2019·Frontiers in Veterinary Science·Bodil Cathrine KochHanne Gredal
Feb 11, 2021·Stroke; a Journal of Cerebral Circulation·Anna Ramos-PachónJoan Montaner
Aug 28, 2021·International Journal of Molecular Sciences·Sebastian AndoneRodica Balasa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Chun-Cheng ChiuI-Chuan Chen
International Journal of Stroke : Official Journal of the International Stroke Society
Ran MengXunming Ji
© 2022 Meta ULC. All rights reserved