Is diabetic retinopathy affected by diabetes type? A retrospective study using electronic medical record data from patients with latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

Acta Diabetologica
Wanyue LiMaonian Zhang

Abstract

To determine whether the occurrence of diabetic retinopathy (DR) and its related factors are affected by diabetes type (latent autoimmune diabetes in adults [LADA], type 1 diabetes mellitus [T1DM], type 2 diabetes mellitus [T2DM]). LADA patients were matched for age (± 2 years) and sex to T1DM (1:1) and T2DM (1:2) patients. Retrieved variables included demographic characteristics, diabetes history, laboratory test findings, and history of DR screening, etc. Multiple logistic regression analysis was applied to identify influencing factors of DR. A decision tree was used to explore interactions between diabetes type and other influencing factors of DR. We included 110 LADA, 101 T1DM, and 220 T2DM patients. DR prevalence was 26.4% in LADA patients, lower than that in T1DM (50.5%) and T2DM (47.7%) patients (P < 0.001). Logistic regression analysis demonstrated that diabetes duration (OR = 1.15, 95% CI: 1.1-1.26, P < 0.001) and diabetic nephropathy (DN) (OR = 42.39, 95% CI: 10.88-165.11, P < 0.001) were independent risk factors for DR, and regular DR screening (OR = 0.33, 95% CI: 0.16-0.69, P = 0.003) was an independent protective factor. Decision tree analysis showed that in patients without DN with a diabetes duration of at least ...Continue Reading

References

Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·M BalmeT M E Davis
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Jan 2, 2004·The New England Journal of Medicine·Robert N Frank
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Tien Yin WongBruce B Duncan
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew S EdwardsKimberley J Hansen
Oct 24, 2008·Diabetes Care·Mohammed I HawaUNKNOWN Action LADA Group
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·P MyhillT M E Davis
Jun 29, 2010·Lancet·Ning CheungTien Yin Wong
Jan 26, 2013·Diabetes·Maria J Redondo
Aug 6, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·C K Kramer, R Retnakaran
Mar 19, 2014·International Journal of Ophthalmology·Hoon ParkJong Seok Park
Jan 21, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·E LaugesenUNKNOWN Danish Diabetes Academy Workshop and Workshop Speakers
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Apr 2, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Simon NusinoviciTien Yin Wong
Aug 5, 2019·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F C SassoUNKNOWN NO BLIND Study Group

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