PMID: 7546596Jan 1, 1995Paper

Is early-onset Alzheimer disease a distinct subgroup within the Alzheimer disease population?

Alzheimer Disease and Associated Disorders
M A RaskindD Bravi

Abstract

Although patients with Alzheimer disease (AD) share major clinical and neurohistologic features regardless of age of onset, the hypothesis that early-onset AD comprises a distinct subgroup remains viable. Most studies addressing this hypothesis find quantitative differences between early- and late-onset AD patients. Early-onset AD is characterized by shorter survival, more rapid cognitive deterioration, greater frequency of language disturbance, more severe and widespread neurochemical abnormalities, and a greater density of neurohistologic lesions. In addition, both the chromosome 14 genetic abnormality and chromosome 21 amyloid precursor protein mutations appear restricted to early-onset familial AD. Age of onset of AD subjects may be relevant to the design of clinical trials. For example, the efficacy of a drug that slows disease progression may be more easily demonstrated in subjects with early-onset disease.

Citations

Sep 18, 1998·Neuropsychologia·T ImamuraE Mori
Feb 7, 2004·Archives of Gerontology and Geriatrics·Roberto GallassiSebastiano Lorusso
Oct 8, 2015·Journal of Alzheimer's Disease : JAD·Nagaendran KandiahHwee Lin Wee
Sep 1, 1996·Journal of the American Geriatrics Society·B C Jost, G T Grossberg
Sep 24, 2005·Dementia and Geriatric Cognitive Disorders·Esther S C KorfFrank-Erik de Leeuw

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