Is early-onset in major depression a predictor of specific clinical features with more impaired social function?

Chinese Medical Journal
Yan-Hong LiuTian-Mei Si

Abstract

Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. In total, 547 out-patients aged 18-65 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4 th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Early-onset MDD (EOD, <30 years) was associated with longer illness (P = 0.003), unmarried status (P < 0.001), higher neuroticism (P ≤ 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients wi...Continue Reading

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Citations

Jun 1, 2021·Journal of Psychiatric Research·David P HerzogKlaus Lieb
Sep 28, 2021·The British Journal of Clinical Psychology·Shefaly ShoreyCeline H J Wong

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SPSS

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