Is edema in minimal change disease of childhood really hypovolemic?

International Urology and Nephrology
Yilmaz TabelSerdal Gungor

Abstract

In this study, we aimed to find out whether children with minimal change disease can be classified as hypervolemic by objective measures. Eighteen children with minimal change disease diagnosed at our department between November 2005 and May 2007 were included in this study. All patients were newly diagnosed or relapsed but were steroid free for at least 6 months. In the first week of edema and when edema resolved (5-7 days after initiation of therapy), weight, height and blood pressure were obtained from all patients. Serum and plasma samples were taken following a starvation period of 12-14 h. The volume load of all patients was evaluated, measuring the inferior vena cava indices in each stage by echocardiography. Average weight at presentation was 8.5% higher than the ideal (dry) weight. There were significant differences between the first and post-treatment body weights, abdomen circumference, and systolic and diastolic blood pressure values (P<0.05 for each). The inferior vena cava index (IVCI) values decreased significantly after diuretic treatment (P<0.001), while inferior vena cava collapsibility index (IVCCI) values increased in the post-treatment period (P<0.001). We believe that a close follow-up of hypervolemic chil...Continue Reading

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Citations

Nov 7, 2012·Nephron. Clinical Practice·Jameela A KariGhadeer Mokhtar
May 2, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Gaurav KapurTej K Mattoo
Sep 3, 2011·Indian Journal of Nephrology·A A IyengarK D Phadke
Aug 17, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andrea PasiniUNKNOWN NefroKid Study Group
Feb 6, 2015·Clinical and Experimental Nephrology·Yoshitsugu KakuUNKNOWN Japanese Society for Pediatric Nephrology

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