PMID: 8951801Nov 1, 1996Paper

Is endothelial cell autocrine production of tumor necrosis factor a mediator of lipid-induced endothelial dysfunction?

Medical Hypotheses
M Toborek, B Hennig

Abstract

Injury or dysfunction of the vascular endothelium is one of the first events in the development of atherosclerosis. Individual lipids, e.g. fatty acids or lipoproteins, are among the most critical factors which may induce injury to the endothelium. Selected fatty acids, such as linoleic acid, can disrupt endothelial barrier function and increase the inflammatory response of the vascular endothelium. The mechanisms of these processes are not fully understood. It is hypothesized that selected fatty acids can mediate the autocrine production of tumor necrosis factor-alpha in endothelial cells. This will activate a variety of intracellular signaling pathways and further potentiate endothelial injury initially induced by fatty acids.

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Citations

Feb 1, 2006·The Journal of Obstetrics and Gynaecology Research·Yoon Ha KimTae Bog Song
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Nitin T AggarwalWilliam B Campbell
Feb 9, 2010·American Journal of Respiratory Cell and Molecular Biology·Tamara MirzapoiazovaJoe G N Garcia

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