Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?

International Journal of Cardiology
Juliana P BorgesE Tibirica

Abstract

Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease. Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh). Peak increase in forearm blood flow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4% vs. ischemic heart disease: 74.1 ± 48.3% and Chagas: 85.1 ± 68.1%; p < 0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin blood flow (p = 0.55). Endothelial microvascular function was...Continue Reading

Citations

Sep 12, 2018·Congenital Heart Disease·Pablo MarinoEduardo Tibirica
Nov 20, 2020·Microvascular Research·Juliana Pereira BorgesMauro Felippe Felix Mediano
Oct 17, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Daniel Arthur Barata KasalEduardo Tibirica
May 1, 2021·Pathogens·Antonia Pino-MarínHector M Medina

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