Abstract
There is a growing understanding of the effects and potential pathophysiological role of the ETs in asthma and several of the criteria required to strongly implicate ET-1 as a mediator in this disease have been fulfilled. However, some of the information is preliminary, equivocal and requires confirmation. Furthermore, the most important and most difficult criteria, the clinical testing of potent and selective ET receptor antagonists in these diseases has not been conducted and will probably not be completed for several years. A critical area of research continues to be the elucidation and classification of the ET receptor subtypes mediating the diverse effects of ET-1 in the lung. The unequivocal determination of the pathophysiological role of the ETs in asthma awaits the results of clinical trials with appropriate compounds. Only after these results will we know whether ET-1 has fulfilled its promise as a key player in lung pathophysiology, rather than being added to the list of purported important mediators with unfulfilled expectations.
Citations
Jul 14, 1999·Life Sciences·R G Goldie, P J Henry
Aug 14, 1999·Life Sciences·A O ValenciaL Rosenfeld
Sep 24, 2002·Pharmacology & Therapeutics·P D'Orléans-JusteJ C Honoré
Jun 18, 2003·Current Opinion in Pharmacology·Lynette B Fernandes, Roy G Goldie
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Mullol, C Picado
Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·J Xu, N S Zhong
Jul 13, 2000·Critical Care Medicine·J J FehrC W Emala
May 22, 1998·Journal of Cardiovascular Pharmacology·R G GoldieP G Knott
May 22, 1998·Journal of Cardiovascular Pharmacology·L B FernandesR G Goldie
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·G W ChalmersN C Thomson
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·F FinsnesO H Skjønsberg
May 2, 2007·BMC Pulmonary Medicine·Camille TailléBruno Crestani
Apr 12, 2001·International Journal of Experimental Pathology·J DubéL P Boulet
Aug 20, 2003·Respiratory Medicine·K SpiropoulosA Koniavitou
Jul 13, 2001·Pulmonary Pharmacology & Therapeutics·R G GoldieP J Henry
Sep 9, 2005·Journal of Cellular Biochemistry·Luca GallelliCarlo Vancheri
Dec 10, 1999·Nature·P J Barnes
Sep 18, 1997·Journal of Applied Physiology·A TheodorouR Lemen