Is energy expenditure in the hamster primarily under homeostatic or circadian control?

The Journal of Physiology
R Refinetti, M Menaker

Abstract

1. In order to discriminate between homeostatic and circadian control of energy expenditure, this paper considers whether a shorter circadian cycle will produce a proportional reduction in energy expenditure (so that expenditure per unit time is conserved) or alternatively whether energy expenditure will be compressed into the shorter cycle (so that energy expenditure per cycle is conserved). To answer this question, we measured energy expenditure in tau mutant hamsters (whose free-running circadian period has been reduced to about 20 h by a single gene mutation) and wild-type hamsters (whose free-running circadian period is about 24 h). 2. In one experiment, the circadian rhythm of running-wheel activity of tau mutant hamsters was compared with that of wild-type hamsters. The rate of running was not affected by the mutation and, consequently, the total amount of activity per cycle was significantly less in mutants than in wild-type hamsters, whereas the total amount of activity per unit time was nearly the same. 3. In a second experiment, we measured energy expenditure by indirect calorimetry. Metabolic rate was not affected by the mutation and, consequently, the total amount of energy expended per cycle was significantly less...Continue Reading

References

Mar 1, 1992·Physiology & Behavior·R Refinetti, M Menaker
Jan 1, 1991·Physiological Reviews·M J Kluger
Sep 2, 1988·Science·M R Ralph, M Menaker
Jan 1, 1994·Journal of Biological Rhythms·K Shimomura, M Menaker
Jan 1, 1993·Leukemia & Lymphoma·M Y Gordon
Apr 1, 1996·Physiology & Behavior·J A Shoemaker, R Refinetti

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Citations

Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Roberto Refinetti
Dec 1, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R Refinetti
Jan 5, 2014·Canadian Journal of Physiology and Pharmacology·Roberto Refinetti
Mar 6, 2002·Biological Research for Nursing·B J Holtzclaw
Feb 10, 1999·The American Journal of Physiology·E L Robinson, C A Fuller

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