Is environmental radon gas associated with the incidence of neurodegenerative conditions? A retrospective study of multiple sclerosis in radon affected areas in England and Wales

Journal of Environmental Radioactivity
Christopher J Groves-KirkbyStephen Rogers

Abstract

To test whether an association exists between radon gas concentration in the home and increased multiple sclerosis (MS) incidence, a retrospective study was undertaken of MS incidence in known areas of raised domestic radon concentration in England and Wales, using The Health Improvement Network (THIN) clinical research database. The study population comprised 20,140,498 person-years of clinical monitoring (males: 10,056,628: 49.93%; females: 10,083,870: 50.07%), representing a mean annual population of 2.5 million individuals. To allow for the possible latency of MS initiation following exposure, data extraction was limited to patients with at least five years registration history with the same GP practice before first diagnosis. Patient records were allocated to one of nine radon concentration bands depending on the average radon level in their postcode sector. MS incidence was analysed by searching for patients with first MS diagnosis over the eight calendar years 2005-2012 inclusive. 1512 new MS cases were diagnosed, 1070 females, 442 males, equivalent to raw incidence rates of 7.51, 10.61 and 4.40 per 10(5) person-years respectively, comparable to previously reported results. Of these new cases, 115 could be allocated to o...Continue Reading

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Citations

Mar 4, 2020·Environmental Science and Pollution Research International·Zeynab Abaszadeh FathabadiAli Asghar Ebrahimi
Apr 14, 2019·Environmental Science and Pollution Research International·Yi-Chen LiSzu-Chieh Chen
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Sep 11, 2021·Scientific Reports·Monire Fallah YakhdaniAli Asghar Ebrahimi

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