Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis?

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Aroldo Gabriele RizzoMario Cottone

Abstract

Epstein-Barr virus (EBV) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (IBD). Even if a relevant plasmocytosis, similar to IBD, is present in microscopic colitis (MC), the frequency of EBV infection in this setting is unknown. We aimed to compare the frequency of colonic EBV infection in patients with MC, ulcerative colitis (UC), and irritable bowel syndrome (IBS). The frequency of colonic EBV infection in biopsies of 30 patients with MC, 30 patients with UC, and 30 controls with IBS was retrospectively assessed. PCR was performed to detect viral EBV DNA in colonic biopsies. In situ hybridization was also performed to identify and localize EBV-encoded small RNA1 and 2 (EBERs) within cells. The presence of EBV DNA was detected in 27 out of 30 MC patients, in 20 out of 30 UC cases, and in none of IBS group. The frequency of EBV DNA in MC was significantly higher compared with that reported in UC (90.0% vs. 66.7%, p=0.03). EBERs+ cells were observed in 18 out of 30 MC patients, in only 3 out of 30 UC patients (60.0% vs. 10.0%, p<0.001), and in none of IBS group. EBV infection is almost always detectable in the colonic mucosa of patients with MC. Further studies are nec...Continue Reading

Citations

Jun 18, 2019·European Journal of Gastroenterology & Hepatology·Shuang WuYu-Qin Li
Apr 28, 2020·BMJ Open Gastroenterology·Catherine ChoiWeizheng Wang
Jul 24, 2020·European Journal of Pediatrics·Chen ChengJialin Yu
Apr 19, 2018·Frontiers in Microbiology·Andrzej GórskiJan Borysowski
May 1, 2021·Cellular and Molecular Gastroenterology and Hepatology·Celia Escudero-HernándezAndreas Münch

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