PMID: 8954002Dec 1, 1996Paper

Is excessive daytime sleepiness characteristic of Prader-Willi syndrome? The effects of weight change

Archives of Pediatrics & Adolescent Medicine
J C Harris, R P Allen

Abstract

To assess nighttime and daytime sleep patterns in patients with Prader-Willi syndrome and to examine the effects of weight change on excessive daytime sleepiness in patients with this disorder. Case series (within-subject design). A university sleep disorders center. Eight patients (5 males and 3 females), ranging in age from 5.5 to 21 years, who met the diagnostic criteria for Prader-Willi syndrome. Overnight sleep polysomnographic recording and daytime Multiple Sleep Latency Test. Four of the 8 patients were restudied after their weight had changed. Changes in the sleep disordered breathing rate and Multiple Sleep Latency Test measures. Sleep-disordered breathing occurred in all patients and was principally characterized by obstructive hypoventilation or episodes of apnea that occurred primarily during rapid eye movement sleep. After weight reduction, 3 patients had respiratory values that were within the broad normal range (disordered breathing rate, < 15 breaths per hour). Statistically significant (P < .05) weight loss effects occurred during nonrapid eye movement sleep (decrease with weight loss, F = 6.243). Excessive daytime sleepiness was documented in 6 of 7 patients who completed the Multiple Sleep Latency Test. Exces...Continue Reading

Citations

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