Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

Neuroscience and Biobehavioral Reviews
Anandh Dhanushkodi, Ashok K Shetty

Abstract

Exposure to enriched environment has been shown to induce robust neuronal plasticity in both intact and injured adult central nervous system, including up-regulation of multiple neurotrophic factors, enhanced neurogenesis in the dentate gyrus of the hippocampus, and improved spatial learning and memory function. Neuronal plasticity, though mostly adaptive and abnormal, also occurs during certain neurodegenerative conditions such as the temporal lobe epilepsy (TLE). The TLE is characterized by hippocampal neurodegeneration, aberrant mossy fiber sprouting, spontaneous recurrent motor seizures, cognitive deficits, and abnormally enhanced neurogenesis during the early phase and dramatically declined neurogenesis during the chronic phase of the disease. As environmental enrichment has been found to be beneficial for treating animal models of Alzheimer's, Parkinson's, and Huntington's diseases, there is considerable interest in determining the efficacy of this strategy for preventing or treating chronic TLE after the initial precipitating brain injury. This review first discusses the proof of principle behind the potential application of the environmental enrichment strategy for preventing or treating TLE after brain injury. The subs...Continue Reading

References

Dec 7, 1979·Brain Research·R A Cummins, P J Livesey
Sep 24, 1990·Brain Research·A K MohammedL Lärkfors
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
Aug 1, 1973·Experimental Neurology·W T Greenough, F R Volkmar
Aug 1, 1972·Journal of Comparative and Physiological Psychology·M R Rosenzweig, E L Bennett
Oct 27, 1995·Science·H Thoenen
Feb 1, 1996·Stroke; a Journal of Cerebral Circulation·B B Johansson
Jun 1, 1996·Behavioural Brain Research·M R Rosenzweig, E L Bennett
Dec 1, 1996·Progress in Neurobiology·A K Shetty, D A Turner
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A ComeryW T Greenough
Apr 1, 1997·Current Opinion in Neurology·J M Parent, D H Lowenstein
Apr 29, 1998·Brain Research. Molecular Brain Research·S RasmusonA H Mohammed
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·C RamponY Hu
Nov 15, 2000·Hippocampus·C Rampon, J Z Tsien

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Citations

May 27, 2008·Cellular and Molecular Life Sciences : CMLS·B Waldau, A K Shetty
Dec 24, 2011·PloS One·Anandh Dhanushkodi, Michael P McDonald
Jan 29, 2011·Developmental Psychobiology·Phyllis E Mann, Kristen J Gervais
Jun 30, 2015·Journal of Tissue Engineering and Regenerative Medicine·Chaitra VenugopalAnandh Dhanushkodi
Jun 8, 2011·Schizophrenia Research·Neal R Swerdlow
Apr 5, 2012·The International Journal of Neuroscience·Lee S StewartO Carter Snead
May 31, 2018·Epilepsy Currents·Nigel C Jones
Feb 26, 2020·Molecular Biology Reports·Isabella Pregardier KlannCristina Wayne Nogueira

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