Is extensive atrial fibrosis in the setting of heart failure associated with a reduced atrial fibrillation burden?

Pacing and Clinical Electrophysiology : PACE
Alexander Burashnikov, Charles Antzelevitch

Abstract

Atrial fibrillation (AF) affects 10-50% of patients with chronic heart failure (HF) and is associated with poor long-term prognosis. AF is commonly associated with atrial structural remodeling (ASR), principally characterized by atrial dilatation and fibrosis. However, the occurrence of AF in the full spectrum of ASR encountered in patients with HF is poorly defined. Experimental studies have presented evidence that extensive ASR can be accompanied with a reduced burden of AF, secondary to a prominent depression of atrial excitability. This reduction in AF burden is associated with severe atrial fibrosis rather than with dilatation. Clinical studies of patients with HF point to the possibility that advanced ASR is associated with a less frequent AF occurrence than moderate ASR. Our goal in this review is to introduce the hypothesis that AF is less likely to occur in severe versus moderate atrial ASR in the setting of HF and that it is severe atrial fibrosis-associated depression of atrial excitability that reduces AF burden.

References

May 15, 1998·Journal of Cardiovascular Electrophysiology·J M PowerA M Tonkin
Mar 19, 2002·Hypertension·Eva GerdtsUNKNOWN Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Apr 3, 2003·The American Journal of Cardiology·William H Maisel, Lynne Warner Stevenson
Jun 5, 2003·Journal of Cardiovascular Electrophysiology·Bruce S StamblerColette M Guiraudon
Nov 8, 2005·Progress in Cardiovascular Diseases·Bas A SchoonderwoerdHarry J G M Crijns
Feb 18, 2006·Circulation Research·Michele MiragoliStephan Rohr
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Feb 6, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Filippos TriposkiadisNikolaos Tsilimingas
Aug 21, 2007·Journal of the American College of Cardiology·Gregg C FonarowUNKNOWN OPTIMIZE-HF Investigators and Hospitals
Dec 6, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michel HaissaguerreNathalie Virag
Apr 12, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christian KnackstedtPatrick Schauerte
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Jan RemesJos G Maessen
Oct 8, 2009·Circulation. Cardiovascular Imaging·Mustafa KurtSherif F Nagueh
Nov 21, 2009·Journal of the American College of Cardiology·L Julian HaywoodUNKNOWN ALLHAT Collaborative Research Group
Feb 25, 2010·Nature Reviews. Cardiology·Alexander Burashnikov, Charles Antzelevitch
Mar 3, 2010·International Journal of Cardiology·Redi PeciniLars Køber
Jul 29, 2011·Clinical Cardiology·Arnljot TveitMorten Grundtvig
Aug 9, 2011·European Heart Journal·UNKNOWN Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)
Nov 15, 2011·Journal of the American College of Cardiology·Pyotr G PlatonovSiew Yen Ho
Feb 5, 2013·Journal of Cardiovascular Electrophysiology·Mehmet AkkayaNassir Marrouche
Mar 19, 2013·The American Journal of Medicine·Jerry H GurwitzAlan S Go
Dec 19, 2013·Circulation. Heart Failure·Rafael KupersteinRobert Klempfner

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Citations

Nov 3, 2020·Cardiovascular Research·Nikolaos G Frangogiannis

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