Is flecainide dangerous in long QT-3 patients?

Pacing and Clinical Electrophysiology : PACE
Roy BeinartMichael Glikson

Abstract

Mutations of the cardiac sodium channel gene, SCN5A, are present in both long-QT and Brugada syndromes. Flecainide is used as a provocative test to unmask the electrocardiogram (ECG) phenotype of the Brugada syndrome, as well as long-term treatment for long QT-3 syndrome, since it shortens the QT interval. We report a case where oral flecainide induced syncope with a Brugada ECG pattern in a patient with known long QT-3 syndrome.

References

Nov 6, 2002·Circulation·Arthur A M WildeUNKNOWN Study Group on the Molecular Basis of Arrhythmias of the European Society of Cardiology

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Citations

Jun 6, 2016·Heart, Lung & Circulation·Kathryn E Waddell-SmithUNKNOWN members of the CSANZ Genetics Council Writing Group
Dec 5, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stephan HohmannChristian Veltmann
Apr 13, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Arthur A M Wilde, Carol Ann Remme
Oct 14, 2016·Circulation. Arrhythmia and Electrophysiology·Ehud ChorinSami Viskin

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