Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?

Allergy, Asthma & Immunology Research
Ting WangGang Wang

Abstract

It is controversial whether folate status is a risk factor for the development of asthma or other allergic diseases. This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Electronic databases were searched to identify all studies assessing the association between folate status and asthma or other allergic diseases. Two reviewers independently assessed the eligibility of studies and extracted data. The relative risk (RR) or odds ratio (OR) with 95% confidence intervals (CI) was calculated and pooled. Twenty-six studies (16 cohort, 7 case-control, and 3 cross-sectional studies) were identified. Maternal folic acid supplementation was not associated with the development of asthma, atopic dermatitis (AD), eczema, and sensitization in the offspring, whereas exposure during early pregnancy was related to wheeze occurrence in the offspring (RR=1.06, 95% CI=[1.02-1.09]). The TT genotype of MTHFR C677T polymorphism was at high risk of asthma (OR=1.41, 95% CI=[1.07-1.86]). It is indicated that maternal folic acid supplementa...Continue Reading

References

Aug 26, 2003·The American Journal of Clinical Nutrition·Rosalie K WoodsMichael J Abramson
Feb 10, 2006·Thorax·B D PatelN J Wareham
Jul 4, 2006·Chemico-biological Interactions·Flore DepeintPeter J O'Brien
Jul 15, 2006·Chest·Sidney S Braman
Oct 7, 2006·The American Journal of Clinical Nutrition·Augusto A LitonjuaDiane R Gold
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R GranellJ Henderson
Dec 5, 2008·Archives of Disease in Childhood·S E HåbergW Nystad
May 5, 2009·The Journal of Allergy and Clinical Immunology·Elizabeth C Matsui, William Matsui
Nov 3, 2009·American Journal of Epidemiology·Melissa J WhitrowMichael J Davies
Mar 20, 2010·The Clinical Respiratory Journal·Betina Heinsbaek ThuesenAllan Linneberg
Jun 22, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yoshihiro MiyakeYoshio Hirota
Oct 22, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anne Kørner BuesoKai-Håkon Carlsen
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Siri E HåbergWenche Nystad
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Feb 8, 2011·Internal Medicine·Mohamed N FarresNaglaa A Arafa
May 12, 2011·European Journal of Clinical Nutrition·B I NwaruS M Virtanen
Aug 26, 2011·Annals of Nutrition & Metabolism·Andrew E CzeizelFerenc Bánhidy
Oct 11, 2011·American Journal of Obstetrics and Gynecology·Marit P MartinussenMichael B Bracken
Oct 29, 2011·The European Respiratory Journal·Marga B M BekkersAlet H Wijga
Oct 9, 2012·The Journal of Allergy and Clinical Immunology·Adesua Y OkupaElizabeth C Matsui
Dec 15, 2012·The Journal of Allergy and Clinical Immunology·Jenny H LinElizabeth C Matsui
May 9, 2013·American Journal of Respiratory and Critical Care Medicine·Joshua BlatterJuan C Celedón
Sep 5, 2013·Allergy, Asthma & Immunology Research·Gary W K WongFanny W S Ko
Sep 6, 2013·The American Journal of Clinical Nutrition·Krista S CriderRobert J Berry
Feb 21, 2014·Nutrition Reviews·Susan B BrownElizabeth R Bertone-Johnson
Mar 4, 2014·Allergy, Asthma & Immunology Research·Yuan Zhang, Luo Zhang
Jul 6, 2014·Allergy, Asthma & Immunology Research·Guicheng ZhangPeter N LeSouëf

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Citations

Jul 3, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·UNKNOWN Nutrition Working GroupAnthony Cheung
Jul 3, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·UNKNOWN Groupe de travail sur la nutritionAnthony Cheung
Aug 16, 2016·American Journal of Respiratory and Critical Care Medicine·Christine L ParrStephanie J London
Mar 29, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Burcin İscanAbdullah Kumral
Nov 23, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·F C DenisonUNKNOWN Royal College of Obstetricians and Gynaecologists
Oct 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amy L WooldridgeKathryn L Gatford
Jul 15, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ying YeWei-Li Yan
Aug 15, 2017·Frontiers in Immunology·Donjete StatovciSilvia Melgar
Jul 6, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Cheng S WangGang Wang
Oct 8, 2018·International Urogynecology Journal·Carolyn D Keagy
Nov 3, 2017·American Journal of Respiratory Cell and Molecular Biology·Tara V SacoNarasaiah Kolliputi
Jan 2, 2021·Frontiers in Public Health·Yacong BoZengli Yu

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Methods Mentioned

BETA
genotyping

Software Mentioned

Stata
GradePro

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