PMID: 109518May 1, 1979

Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

The Journal of Immunology : Official Journal of the American Association of Immunologists
P ErbM Feldmann


The possibility that the antigen-presenting "macrophages" interacting with helper cells either directly or via the intermediary action of a soluble factor consisting of Ia antigen and a fragment of immunogen, termed GRG (genetically related factor), are a site of Ir gene action was investigated by using the synthetic polypeptide antigen (T,G)-A--L. It was found that T cells from (responder x nonresponder) F1 mice were stimulated by responder "macrophages" or GRF derived from these cells but not by the nonresponder macrophages of GRF from these cells. This suggests that the defect in helper cell induction in nonresponders is at the level of the presenting cell and that the macrophage factor GRF is a soluble Ir gene product. This conclusion was supported by the observation that there was normal presenting cell and GRF function in nonresponders, mouse strains such as CBA that yield helper cells and helper factor with (T,G)-A--L and have defects elsehwere.

Related Concepts

Dose-Response Relationship, Immunologic
Ir Genes
Mice, Inbred CBA
Mice, Inbred C57BL
Protein Biosynthesis

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