PMID: 2117556Aug 20, 1990Paper

Is glucose the sole source of tissue browning in diabetes mellitus?

FEBS Letters
J V Hunt, S P Wolff

Abstract

Reactions between glucose and protein are held to be responsible for the protein 'browning' reactions which occur in diabetes mellitus. In vitro, however, the formation of such novel protein fluorophores is dependent upon the metal-catalysed oxidation of the monosaccharide (glucose 'autoxidation'). Since other small oxidisable molecules are capable of 'browning' proteins via similar metal-catalysed oxidative mechanisms we suggest that protein modification in diabetes may not be restricted to reactions with monosaccharides but may also include other small autoxidisable molecules.

References

Apr 1, 1979·Metabolism: Clinical and Experimental·M B Waitzman
Feb 1, 1979·Experimental Eye Research·F A AsselbergsH Bloemendal
Mar 1, 1990·Diabetes·S BevilacquaE Ferrannini
Aug 15, 1989·Biochemical and Biophysical Research Communications·J V Hunt, R T Dean
Nov 1, 1988·Experimental Eye Research·B J Ortwerth, P R Olesen
Mar 15, 1988·The Biochemical Journal·R Taylor, L Agius
Feb 15, 1988·The Biochemical Journal·J V HuntR T Dean
Aug 31, 1988·Biochimica Et Biophysica Acta·B J Ortwerth, P R Olesen
Jul 1, 1988·Experimental Eye Research·B J OrtwerthP R Olesen
Dec 1, 1986·Archives of Biochemistry and Biophysics·D GarlandJ Kinoshita
Feb 13, 1986·The New England Journal of Medicine·V M MonnierR R Kohn
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Jun 1, 1981·Metabolism: Clinical and Experimental·S SomI B Chatterjee

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Citations

Oct 1, 1995·Diabetes/metabolism Reviews·P S Van DamB Bravenboer
Jan 25, 1993·Atherosclerosis·J V HuntM J Mitchinson
Dec 1, 1994·Atherosclerosis·J V HuntM J Mitchinson
Jul 20, 1994·Biochimica Et Biophysica Acta·P Finotti, S Manente
Jan 1, 1991·Free Radical Biology & Medicine·S P WolffJ V Hunt
Jan 1, 1997·Free Radical Biology & Medicine·P J CoussonsJ V Hunt
Jan 1, 1993·Eye·W G John, E J Lamb
Dec 1, 1991·The Proceedings of the Nutrition Society·J J Strain
May 1, 1991·Journal of Clinical Pathology·K JobstA Horvath
Feb 1, 1996·Redox Report : Communications in Free Radical Research·J V Hunt
Apr 1, 1994·Cytometry·J V HuntM J Mitchinson
Mar 1, 1992·Annals of Clinical Biochemistry·C A Le GuenJ Lunec

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