Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development

Critical Reviews in Microbiology
Jennifer L EdwardsKate L Seib

Abstract

Gonorrhea is a major, global public health problem for which there is no vaccine. The continuing emergence of antibiotic-resistant strains raises concerns that untreatable Neisseria gonorrhoeae may become widespread in the near future. Consequently, there is an urgent need for increased efforts towards the development of new anti-gonococcal therapeutics and vaccines, as well as suitable models for potential pre-clinical vaccine trials. Several current issues regarding gonorrhea are discussed herein, including the global burden of disease, the emergence of antibiotic-resistance, the status of vaccine development and, in particular, a focus on the model systems available to evaluate drug and vaccine candidates. Finally, alternative approaches to evaluate vaccine candidates are presented. Such approaches may provide valuable insights into the protective mechanisms, and correlates of protection, required to prevent gonococcal transmission, local infection and disease sequelae.

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Citations

Apr 3, 2016·Sexually Transmitted Infections·Evgeny A Semchenko, Kate L Seib
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Mar 18, 2017·Infectious Diseases·Marieke L M JenniskensSteven F T Thijsen
Mar 9, 2018·Future Microbiology·Charlene M Kahler
Mar 31, 2018·Current Opinion in Infectious Diseases·Jennifer L EdwardsKate L Seib
Mar 17, 2018·FEMS Microbiology Reviews·Francesca MicoliRoberto Adamo
May 26, 2017·Clinical Microbiology Reviews·Kawthar BouchemalPhilippe M Loiseau
Sep 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jian ZhanYaoqi Zhou
Sep 1, 2017·Nature Reviews. Urology·Magnus Unemo, Aleksandra E Sikora
Nov 23, 2019·Nature Reviews. Disease Primers·Magnus UnemoJo-Anne R Dillon
May 31, 2017·Critical Reviews in Microbiology·N Y Wang, A J Pollard
Feb 17, 2019·Pathogens and Disease·Pavithra JayasundaraJames G Wood
Nov 5, 2019·Frontiers in Immunology·Michael W RussellScott D Gray-Owen
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·J P SevillaMarc Lipsitch
Dec 15, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evgeny A SemchenkoKate L Seib
Jun 8, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Yingxia HeTie Chen
Oct 31, 2021·Nature Reviews. Urology·Evgeny A Semchenko, Kate L Seib

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Methods Mentioned

BETA
nucleic acid amplification
chips

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