Is haemozoin a target for antimalarial drugs?

Annals of Tropical Medicine and Parasitology
S R Meshnick

Abstract

Malarial parasites utilize a unique pathway to degrade haemoglobin. Most of the haem which is released during haemoglobin degradation is incorporated into haemozoin. The mechanism of haemozoin synthesis and the structure of haemozoin are controversial. Neither chloroquine nor artemisinin appear to affect haemozoin synthesis in vivo. Artemisinin is activated by intraparasitic haem and iron into a free radical which then alkylates specific malarial proteins.

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Citations

Sep 28, 2005·Expert Opinion on Therapeutic Targets·Henry LaiNarendra P Singh
Nov 11, 2017·Journal of Tropical Medicine·Siti Junaidah AhmadNoraziah Mohamad Zin
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Nov 19, 2002·International Journal for Parasitology·David J Sullivan

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