Is Herceptin(®) (trastuzumab) by subcutaneous a mini revolution? Pharmaco-economic study

Bulletin du cancer
Vincent LieutenantBarbara Lortal-Canguilhem

Abstract

Herceptin(®) injected by intravenous (IV) is one of the key treatment of breast cancer HER2+. The improvement of galenic form allowed a new way of administration, the sub-cutaneous way (SC), authorized by EMEA in 2013. This new way enables a 5-minute infusion, a fixed dose and a fixed volume of preparation. On 2012, saving-time and financial impacts were calculated by extrapolation of the IV way in a cancer treatment center. The study showed a preparing time-saving of 7.5min/loading dose and of 6.5min/maintenance dose, and a nurse time-saving of 4.5min/loading dose and 4.25min/maintenance dose. Moreover, it can be added a saving of consumable of 13,31€ per injection in case of monotherapy. The SC leads to a new adaptation and reorganization in the preparation of monoclonal antibodies and day hospitals.

Citations

Jun 4, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G Lopez-VivancoJ De la Haba-Rodríguez
Jul 26, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Beate BittnerJohannes Schmidt
Dec 5, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Shereef ElsamanyMohamed Jafal

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