Is HIV infection a TNF receptor signalling-driven disease?

Trends in Immunology
G Herbein, Kashif Aziz Khan

Abstract

Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both to apoptosis of uninfected bystander T cells and to sustained viral replication in infected T cells and macrophages. This article proposes a model that highlights the role of HIV proteins in the modulation of TNF receptor signalling and could explain both immune suppression and the formation of viral reservoirs during HIV infection.

References

Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J K WangD Trono
Apr 27, 2001·Trends in Immunology·U Mahlknecht, G Herbein
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tae-Wook ChunAnthony S Fauci
Apr 24, 2004·The Journal of General Virology·Samantha Cooray
May 15, 2004·DNA and Cell Biology·Karuppiah MuthumaniDavid B Weiner
Jan 11, 2005·Current HIV Research·Joshua L Andersen, Vicente Planelles
Apr 29, 2005·AIDS Patient Care and STDs·N WigJ P Wali
Jul 19, 2005·Current HIV Research·Anne Zelie DecrionGeorges Herbein
Sep 13, 2005·The Journal of Biological Chemistry·Grant R CampbellStephen A Spector
Mar 7, 2006·PLoS Pathogens·Masmudur M Rahman, Grant McFadden
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Sep 19, 2006·Experimental Cell Research·Michael H LehmannVolker Erfle
Nov 4, 2006·Cell Death and Differentiation·E RitsouP H Krammer
Dec 26, 2006·Trends in Immunology·James L Riley, Carl H June

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Citations

Mar 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Guzmán-FulgencioS Resino
Oct 28, 2009·Current Infectious Disease Reports·Leslie A BruggemanRobert C Kalayjian
Jan 1, 2010·Cell Death & Disease·N W Cummins, A D Badley
Feb 10, 2010·Nature Reviews. Rheumatology·Seo Young Kim, Daniel H Solomon
Oct 22, 2008·AIDS Research and Human Retroviruses·P MorlatUNKNOWN ANRS CO8 Aproco-Copilote Study Group
May 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert C KaplanRussell P Tracy
Jul 28, 2009·Annual Review of Medicine·Mirko PaiardiniGuido Silvestri
May 2, 2012·Advances in Virology·W Abbas, G Herbein
Apr 13, 2010·Retrovirology·Georges Herbein, Audrey Varin
Apr 13, 2010·Retrovirology·Georges HerbeinWasim Abbas
Feb 8, 2011·PloS One·Susana AlvarezMa Ángeles Muñoz-Fernández
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Mark R Zielinski, James M Krueger
Jan 24, 2014·Mediators of Inflammation·Amit KumarGeorges Herbein
Jun 15, 2010·Current Opinion in HIV and AIDS·Petronela AncutaRafick-Pierre Sekaly
Apr 4, 2015·Viruses·Wasim AbbasGeorges Herbein
Mar 1, 2009·Expert Opinion on Medical Diagnostics·Irene Meester, Juan Manuel Solis-Soto
Sep 8, 2010·Pharmacology & Therapeutics·Simona FiorentiniArnaldo Caruso
Aug 5, 2008·Trends in Immunology·Ivona PandreaCristian Apetrei
Jun 6, 2008·Trends in Immunology·István BarthaViktor Müller
Jun 29, 2013·Biochimica Et Biophysica Acta·Wasim Abbas, Georges Herbein
Jun 25, 2013·FEMS Microbiology Reviews·Mariya I PetrovaSarah Lebeer
Dec 23, 2014·Cytokine & Growth Factor Reviews·Zulema Antonia PercarioElisabetta Affabris
Jul 1, 2017·International Journal of Molecular Sciences·Francesca SpadaroLaura Fantuzzi
Aug 23, 2017·Viruses·Himanshu Garg, Anjali Joshi
Dec 7, 2017·Mediators of Inflammation·T SokoyaT M Rossouw
Aug 16, 2018·The Journal of Gene Medicine·Swati Ahir-BistJayanti Mania-Pramanik
Feb 9, 2018·Scientific Reports·Santanu BiswasKrishnakumar Devadas
Aug 8, 2015·The European Respiratory Journal·Theresa M RossouwCharles Feldman
Aug 30, 2013·The Open Virology Journal·Wasim Abbas, Georges Herbein
Jan 1, 2010·Journal of Leukocyte Biology·Edana CassolGuido Poli
Oct 6, 2009·Journal of Leukocyte Biology·Laetitia RedelChristian Schwartz
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie GosselinPetronela Ancuta
Oct 12, 2018·The Journal of Dermatological Treatment·Andrea Montes-TorresUNKNOWN ; the BIOBADADERM Study Group and Psoriasis Group of the AEDV

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