PMID: 7581587Jan 1, 1995Paper

Is HRT indicated for the prevention of cardiovascular disease?

International Journal of Fertility and Menopausal Studies
G Samsioe

Abstract

There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less well-defined, effects on various diseases; but observational studies suggest a decrease also in the overall mortality in estrogen users compared to nonusers. The critique of this concept is mainly that there is but one small clinical trial, and that observational data may be subject to confounders and biases. Questions have been raised whether the estrogen user comes from a preselected healthier population. Several of the observational studies are large enough to control for preexisting morbidity, including risk factors of cardiovascular disease. If anything, it would seem that women carrying risk factors inclusive of a sustained myocardial infarction are even better off (yielding a relative risk of 0.2) than those without risk factors. In order to protect the endometrium from malignant transformation and to ensure an acceptable bleedi...Continue Reading

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