PMID: 18409290Apr 16, 2008Paper

Is hypotensive effectiveness of amlodipine therapy in smokers connected with endothelin-1 (ET-1) concentration?

Przegla̧d lekarski
Hanna Kara-PerzStanisław Perz

Abstract

An interaction between a vasoconstrictive factor--endothelin-1 (ET-1) and nicotine is currently a subject of investigations. Many studies make us consider whether worse hypotensive effectiveness of many antihypertensive agents applied in smokers may be connected with elevated ET-1 level. The aim of this study was evaluation of hypotensive effectiveness of amlodipine in smoking (group A) and non-smoking (group B) hypertensive subjects. Assessment of plasma ET-1 concentration in group A and B and evaluation of influence of 30-day amlodipine therapy on plasma ET-1 concentration in group A and B. The examined group comprised 31 patients with essential hypertension (grade I and II). The result of the amlodipine therapy (5 mg/day) was statistically significant decrease in systolic (SBP) and diastolic (DBP) blood pressure in group B. In group A non-significant reduction of SBP and DBP was observed. In group A plasma ET-1 concentration was significantly higher than in group B. We noticed non-significant decrease in plasma ET-1 concentration in both groups. These results do not prove the hypothesis that worse hypotensive effectiveness of amlodipine applied in smokers may be connected with elevated ET-1 level. Despite of higher ET-1 conc...Continue Reading

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue européenne pour les sciences médicales et pharmacologiques
A AmorosoG Sportelli
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
L SeguiasB Montane
© 2022 Meta ULC. All rights reserved