Is hypoxia a factor in the progression of pulmonary sarcoidosis?

Revue des maladies respiratoires
F JenyV Besnard

Abstract

Sarcoidosis is a systemic granulomatous disease that can reduce life expectancy mainly due to pulmonary fibrosis resulting from granulomatous inflammation The lack of vascularization within pulmonary granulomas suggests that macrophages localized in the center of these structures are hypoxic. Hypoxia signaling pathways are known to be pro-inflammatory and pro-fibrotic in various pathological conditions. Recent data suggest an involvement of the transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of sarcoidosis. This could represent a new research approach for the understanding and therapeutic management of sarcoidosis.

References

Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·Argyris TzouvelekisVassilis Aidinis
Mar 19, 2008·Infection and Immunity·Laura E ViaClifton E Barry
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeon-Ok MoonBryan L Copple
Oct 23, 2009·Annals of the New York Academy of Sciences·Volker H Haase
Jul 24, 2010·The European Respiratory Journal·M KambouchnerJ-F Bernaudin
Oct 5, 2013·Lancet·Dominique ValeyreJoachim Müller-Quernheim
Oct 30, 2015·The FEBS Journal·Laura D'IgnazioSonia Rocha
Apr 14, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Osamu ManabeNagara Tamaki
Jul 9, 2016·Current Opinion in Pulmonary Medicine·Florence JenyJean-François Bernaudin
Sep 7, 2016·The Journal of Clinical Investigation·Nan Lin, M Celeste Simon
Aug 5, 2017·The European Respiratory Journal·Boris DuchemannHilario Nunes
Jul 6, 2019·Nature Reviews. Disease Primers·Johan GrunewaldJoachim Müller-Quernheim

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