Is ibrutinib associated with disseminated cryptococcosis with CNS involvement?

Cancer Biology & Therapy
Muhammad Bilal AbidNathan D Gundacker

Abstract

Chronic lymphocytic leukemia (CLL) is a disorder of B cells that affects humoral as well as cell-mediated immunity. Protection against cryptococcal infections is mounted by an intricate and synchronized interplay of both integral arms of immunity. Whether CLL or small molecule tyrosine kinase inhibitors are independently predisposing hosts to cryptococcal infections remain to be explored. Herein, we present a report of a patient who developed disseminated cryptococcosis while receiving ibrutinib therapy for CLL in the salvage setting. We further present relevant literature available thus far on the topic and discuss immunologic mechanisms that may be involved in the fungal pathogenesis in such patients.

References

Mar 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara A MirzaRana A Hajjeh
Apr 12, 2003·Blood·Wendelina J M MackusMarinus H J Van Oers
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiaorong Lin
Jul 9, 2011·Nature Immunology·E John Wherry
Jul 6, 2014·Cold Spring Harbor Perspectives in Medicine·Kyung J Kwon-ChungYong-Sun Bahn
Dec 8, 2015·The New England Journal of Medicine·Jan A BurgerUNKNOWN RESONATE-2 Investigators
May 10, 2017·Open Forum Infectious Diseases·Julia A MessinaJohn R Perfect

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Citations

Aug 7, 2019·Journal of Fungi·Justin BeardsleySharon C-A Chen
Aug 11, 2020·Médecine et maladies infectieuses·J BrochardD Boutoille

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Methods Mentioned

BETA
X-ray

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