Is immune checkpoint inhibitor-associated diabetes the same as fulminant type 1 diabetes mellitus?

Clinical Medicine : Journal of the Royal College of Physicians of London
Angelos KyriacouPunith Kempegowda

Abstract

Pembrolizumab is an anti-cancer drug that targets programmed cell death protein-1 (PD-1) receptors on lymphocytes resulting in their activation against tumour cells. PD-1 receptors are also interspersed in endocrine organs and pembrolizumab use has long been associated with hypophysitis and thyroiditis. Since the introduction of immune checkpoint inhibitors (ICI), several cases of fulminant type 1 diabetes mellitus (FT1DM) have been reported. However, it is unclear if FT1DM and ICI-induced diabetes are the same pathology. We review the existing literature of ICI-induced diabetes to investigate its nature and to what extent it represents type 1A diabetes and/or FT1DM (type 1B diabetes) using an example case. Our review showed that ICI-induced diabetes may be a different entity to FT1DM. Furthermore, there is limited evidence for the management of ICI-induced T1DM. Further research into its pathophysiology will improve management and possibly prevent this burdensome complication.

References

Oct 29, 2000·The American Journal of Gastroenterology·S NairC S Pitchumoni
Jul 29, 2003·Diabetes Care·Akihisa ImagawaHideichi Makino
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shing-Jia ShiehHuey-Kang Sytwu
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Mar 26, 2015·Diabetes Care·Jing HughesKevan C Herold
Apr 2, 2015·Cancer Immunology, Immunotherapy : CII·Juan Martin-LiberalJames Larkin
Jun 28, 2015·Diabetes Care·Mahnaz MellatiIrl B Hirsch
Aug 28, 2015·Diabetes Care·Caroline GaudySophie Béliard
Apr 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lars HofmannLucie M Heinzerling
Nov 3, 2016·Journal of Diabetes Investigation·Masahide OkamotoHirotaka Shibata
Jun 15, 2016·The Tohoku Journal of Experimental Medicine·Yuka MiyoshiYu Oyama
Jun 24, 2016·The Journal of Dermatology·Yukiko TeramotoAkifumi Yamamoto
Oct 4, 2016·International Journal of Hematology·Wataru MunakataKensei Tobinai
Dec 27, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuko UsuiKoichi Goto
Jan 4, 2017·Journal of the National Cancer Institute·Claire F FriedmanMichael A Postow
Jan 4, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G H TelóA P Fay
Jan 21, 2017·Nature Reviews. Endocrinology·David J ByunMonica Girotra
May 19, 2017·Journal for Immunotherapy of Cancer·James Luke GodwinColleen Veloski
Jun 15, 2017·Case Reports in Oncology·Li LiAlan B Grosbach
Jun 22, 2017·Cancer Immunology, Immunotherapy : CII·Marie-Léa GauciJean-François Gautier
Aug 24, 2017·International Journal of Cancer. Journal International Du Cancer·Yingcheng WuHuiqun Wu
Sep 1, 2017·Melanoma Research·Aikaterini TsiogkaPeter Koelblinger
Sep 8, 2017·Immunotherapy·Matthew A Smith-CohnIgnacio Garrido-Laguna
Oct 24, 2017·Endocrinología, Diabetes Y Nutrición·Chadia Mizab MellahMarta Hernández García
Oct 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lucien MarchandPierre Saintigny
Nov 4, 2017·Journal of Diabetes Investigation·Ryo KumagaiHiroaki Yagyu
Dec 20, 2017·Journal for Immunotherapy of Cancer·Pouyan N ChangizzadehVincent A Armenio
Jan 18, 2018·Clinical Lymphoma, Myeloma & Leukemia·Elaine ChangSarvari V Yellapragada
Jan 19, 2018·The Tohoku Journal of Experimental Medicine·Kanako SakuraiZenei Arihara
Jan 31, 2018·BMJ Case Reports·Ricardo CapitaoCatarina Saraiva
Feb 1, 2018·Advanced Emergency Nursing Journal·Joshua VillarrealKumhee Ro
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Feb 22, 2018·Diabetes Care·Lucien MarchandCharles Thivolet

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Citations

Jul 31, 2021·World Journal of Diabetes·Carly YimTerra Arnason

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