Is infant arterial stiffness associated with maternal blood pressure in pregnancy? Findings from a UK birth cohort (Baby VIP study)

PloS One
Ka Ying Bonnie NgNisreen A Alwan

Abstract

In adults, arterial stiffness measured by pulse wave velocity (PWV) is regarded as a predictor of cardiovascular disease. Infant vascular development depends on factors related to pregnancy, including maternal blood pressure (BP). This study assessed the association between maternal BP in pregnancy and infant brachio-femoral PWV at age 2-6 weeks. The Baby Vascular health and Iron in Pregnancy (Baby VIP) study is a birth cohort which measured PWV and heart rate (HR) in 284 babies in Leeds, UK, at 2-6 weeks after birth. Maternal BP measurements at 12 and 36 weeks gestation was collected from antenatal clinical records. Multivariable linear regression models assessed associations between maternal systolic and diastolic BPs, and BP change from booking to 36 weeks, with infant PWV adjusting for covariables at both mother and baby level. There was no evidence of an association between infant PWV and maternal systolic BP at booking (adjusted regression coefficient -0.01 m/s per 10mmHg, 95% CI -0.11, 0.14, p = 0.84) or at 36 weeks (adjusted regression coefficient 0.00 m/s per 10mmHg, 95% CI -0.12, 0.11, p = 0.95). Change between 12 and 36 weeks gestation of more than 30 mmHg in systolic BP or 15 mmHg in diastolic BP was also not associ...Continue Reading

References

Oct 1, 1991·British Journal of Obstetrics and Gynaecology·D S SeidmanY L Danon
Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Aug 1, 1982·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·A A Laogun, R G Gosling
Jan 1, 1980·Acta paediatrica Scandinavica·K K Ibsen, M Grønbaek
Jul 1, 1980·Hypertension·S H ZinnerE H Kass
Jan 2, 1993·BMJ : British Medical Journal·C M LawC H Fall
Apr 17, 2001·BMJ : British Medical Journal·G BeeversE O'Brien
Mar 19, 2002·Hypertension·Michel E SafarGérard M London
Mar 8, 2003·Hypertension·Empar LurbeJosep Redón
Feb 5, 2004·The Journal of Pediatrics·Matthew W GillmanSteven E Lipshultz
Nov 4, 2004·Current Topics in Developmental Biology·Cassandra M KelleherRobert P Mecham
Nov 18, 2004·Heart·P Rachael James, Catherine Nelson-Piercy
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Jun 21, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rutger W van der MeerHildo J Lamb
Apr 28, 2010·Korean Circulation Journal·Yiu-Fai Cheung
May 26, 2010·Journal of Hypertension·Elena M van Leeuwen-SegarceanuJohanna H van der Lee
Jul 27, 2010·Archives of Cardiovascular Diseases·Byoung-Jin ParkYong-Jae Lee
Oct 5, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yousef ShahinIan Chetter
Apr 17, 2014·BMJ : British Medical Journal·Kate BramhamLucy C Chappell
Oct 11, 2014·Neonatology·Sharon ChenElif Seda Selamet Tierney

❮ Previous
Next ❯

Software Mentioned

GeoConvert
Vicorder
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.