Is initial excision of cutaneous melanoma by General Practitioners (GPs) dangerous? Comparing patient outcomes following excision of melanoma by GPs or in hospital using national datasets and meta-analysis

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P MurchieAmanda J Lee

Abstract

Melanomas are initially excised in primary care, and rates vary internationally. Until now, there has been no strong evidence one way or the other that excising melanomas in primary care is safe or unsafe. European guidelines make no recommendations, and the United Kingdom (UK) melanoma guidelines require all suspicious skin lesions to be initially treated in secondary care based on an expert consensus, which lacks supporting evidence, that primary care excision represents substandard care. Despite this, studies have found that up to 20% of melanomas in the UK are excised by general practitioners (GPs). Patients receiving primary care melanoma excision may fear that their care is substandard and their long-term survival threatened, neither of which may be justified. Scottish cancer registry data from 9367 people diagnosed with melanoma in Scotland between 2005 and 2013 were linked to pathology records, hospital data and death records. A Cox proportional hazards regression analysis, adjusting for key confounders, explored the association between morbidity and mortality and setting of primary melanoma excision (primary versus secondary care). A pooled estimate of the relative hazard of death of having a melanoma excised in primar...Continue Reading

Citations

Jun 20, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Peter MurchieAmanda J Lee
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Lavinia Ferrante di RuffanoUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Naomi ChuchuUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Naomi ChuchuUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 7, 2018·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Apr 17, 2020·BJGP Open·Andrea L SmithUNKNOWN Australian Melanoma Centre of Research Excellence Study Group
Sep 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Channay NaidooHeidi Abrahamse
May 26, 2020·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·E HarkemanneI Tromme
Dec 29, 2020·Cancer Epidemiology·Adele C GreenDavid C Whiteman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.