Is intercompartmental urea clearance during hemodialysis a perfusion term? A comparison of two pool urea kinetic models.

Journal of the American Society of Nephrology : JASN
D SchneditzN W Levin

Abstract

Analyses of intradialytic and postdialytic urea profiles call for models that consider delayed urea transfer from different parts of the body to the blood. There are two different approaches to the problem. In the classical cell membrane model it is assumed that the two compartments refer to the serial (s) arrangement of extracellular and intracellular volumes, whereas in the regional blood flow model the two compartments are identified as parallel (p) organ systems with high or low perfusion. In the cell membrane model, delayed urea removal from peripheral body compartments is governed by intercompartmental clearance (Kc) which is a function of cell membrane permeability, whereas in the regional blood flow model delayed urea removal is related to low perfusion (QL) of the large muscle/skin/bone compartment. Both models were compared in a set of 16 high-efficiency hemodialysis treatments. Modeled volumes (Vm,s = 31.2 +/- 9.5 L; Vm,p = 30.0 +/- 8.3 L) and modeled dose of hemodialysis (Kt/Vm,s = Kt/Vm,p = 1.12 +/- 0.33) were the same for both models. However, volumes modeled by either technique were significantly lower than anthropometric volumes (V alpha = 35.0 +/- 6.4 L). These data suggest that at this point the two models are...Continue Reading

Citations

May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D SchneditzN W Levin
Dec 25, 2013·The International Journal of Artificial Organs·Evangelia C DounousiKonstantinos P Katopodis
Mar 18, 2000·Kidney International·M ZiółkoJ Grabska-Chrzastowska
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·W R ClarkE F Vonesh
Aug 8, 2001·Seminars in Dialysis·D Schneditz, J T Daugirdas
Oct 11, 2001·Advances in Renal Replacement Therapy·T A Depner
Mar 12, 2004·Computer Methods and Programs in Biomedicine·Manuel PradoJosé Antonio Milán
Oct 24, 2000·Kidney International·A SharmaC Rodd
Jul 16, 2004·Kidney International·Salvatore Di FilippoFrancesco Locatelli
Nov 14, 1997·Kidney International·J T DaugirdasG Schulman
Feb 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nigel S KanagasundaramUNKNOWN Project for the Improvement of the Care of Acute Renal Dysfunction Study Group
Feb 13, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel SchneditzJohn T Daugirdas
Mar 10, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Céline DheuMichel Fischbach
Aug 24, 2010·Computers in Biology and Medicine·J Fernandez de Canete, P Del Saz Huang

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