Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?

American Journal of Respiratory and Critical Care Medicine
Richard LeighMark D Inman

Abstract

Interleukin (IL)-13 is regarded as being a central effector in the pathophysiology of airway hyperresponsiveness. We have described a mouse model in which chronic allergen exposure results in sustained airway hyperresponsiveness and aspects of airway remodeling, and here sought to demonstrate that this component of airway hyperresponsiveness is independent of biologically active IL-13. Sensitized mice were subjected to either brief or chronic periods of allergen exposure and studied 24 hours after brief or 4 weeks after chronic allergen inhalation. A soluble murine anti-IL-13 receptor fusion protein that specifically binds to and neutralizes IL-13 was given daily during the 4 days before the day of outcome measurements in both protocols. Outcome measurements included airway responses to intravenous methacholine, bronchoalveolar lavage fluid cell counts, and airway morphometry. Compared with the saline control, brief allergen challenge resulted in airway hyperresponsiveness, which was prevented by anti-IL-13 treatment. Chronic allergen challenge resulted in sustained airway hyperresponsiveness and indices of airway remodeling; IL-13 blockade failed to reverse this sustained airway hyperresponsiveness. These results confirm that ...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·B R WiggsJ C Hogg
Mar 11, 1989·Lancet·W R RocheS T Holgate
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Nov 1, 1993·The American Review of Respiratory Disease·K KuwanoJ C Hogg
Feb 1, 1993·The American Review of Respiratory Disease·N CarrollA James
Jun 20, 1998·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·L P BouletM Laviolette
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·W BusseS Banks-Schlegel
Sep 18, 1999·The European Respiratory Journal·C LapriseL P Boulet
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·M D InmanP M O'Byrne
Oct 19, 1999·The Journal of Clinical Investigation·J A EliasR J Homer
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·E PalmansR A Pauwels
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Aug 5, 2000·Journal of Applied Physiology·G A VolgyesiA S Slutsky
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·A TrifilieffC Bertrand
Feb 15, 2001·The New England Journal of Medicine·W W Busse, R F Lemanske
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J MattesP S Foster
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·M YangP S Foster
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·P K Jeffery
Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brian MorseCraig M Lilly
Feb 13, 2002·The American Journal of Pathology·Kate BleaseCory M Hogaboam
Jun 29, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H TanakaH Nagai
Oct 25, 2002·American Journal of Respiratory Cell and Molecular Biology·Richard LeighMark D Inman
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Richard LeighPaul M O'Byrne
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian TaubeErwin W Gelfand
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Marsha Wills-Karp, Monica Chiaramonte
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Mark Inman
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Nives Zimmermann, Marc E Rothenberg
Feb 6, 2003·The Journal of Clinical Investigation·Jack A EliasZhou Zhu
Mar 5, 2003·Annual Review of Immunology·Thomas A Wynn
Mar 12, 2003·Chest·Paul M O'Byrne, Mark D Inman
Sep 19, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Russ EllisMark D Inman
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Richard LeighMark D Inman

❮ Previous
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Citations

Aug 19, 2007·Current Allergy and Asthma Reports·Yasuhiro Tabata, Gurjit K Khurana Hershey
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Esteban J Morcillo, Julio Cortijo
May 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Haihong JiangYaping Tu
Jan 6, 2007·American Journal of Respiratory and Critical Care Medicine·Paul ForsytheJohn Bienenstock
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Yanbing MaZhikang Peng
Oct 14, 2008·American Journal of Respiratory and Critical Care Medicine·David S SouthamMark D Inman
Jan 31, 2009·American Journal of Respiratory and Critical Care Medicine·Jennifer KearleyClare M Lloyd
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Lisa G GregoryClare M Lloyd
Mar 26, 2005·American Journal of Respiratory and Critical Care Medicine·Leonardo FabbriEdward Abraham
Nov 26, 2004·American Journal of Respiratory Cell and Molecular Biology·Margaret M KellyJack Gauldie
Mar 9, 2013·American Journal of Respiratory Cell and Molecular Biology·Yanbing MaZhikang Peng
Dec 19, 2008·Disease Models & Mechanisms·Anthony T Nials, Sorif Uddin
Apr 12, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Soojin ParkHyunsu Bae
Jan 5, 2013·Current Rheumatology Reports·Matthew B Greenblatt, Antonios O Aliprantis
May 26, 2010·Experimental Lung Research·Eric CareauElyse Y Bissonnette
Dec 22, 2015·The Journal of Allergy and Clinical Immunology·Frank KirsteinFrank Brombacher
Feb 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H H Kariyawasam, D S Robinson
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T TanabeM Yamaya
Jan 9, 2015·American Journal of Respiratory Cell and Molecular Biology·Jean-François Lauzon-JosetElyse Y Bissonnette
Apr 7, 2015·Respiratory Physiology & Neurobiology·M Allen McAlexanderBradley J Undem
Aug 2, 2008·The Journal of Allergy and Clinical Immunology·Jennifer KearleyClare M Lloyd
Feb 7, 2006·European Journal of Pharmacology·Toshiyuki Yamagata, Masakazu Ichinose
Oct 28, 2008·Pharmacology & Therapeutics·Michael R EdwardsSebastian L Johnston
Dec 31, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RobinsonP Nair
Nov 7, 2014·Allergy, Asthma & Immunology Research·Chian-Jiun LiouJiann-Jong Shen
Jan 16, 2018·Expert Opinion on Investigational Drugs·Polyxeni NtontsiGeorgios Hillas
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eric CareauElyse Y Bissonnette
Jul 22, 2014·Journal of Cellular Biochemistry·David G ChapmanCharles G Irvin
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Gaoyun YangAnuk M Das
Dec 24, 2019·Frontiers in Pharmacology·Giancarlo MaroneGilda Varricchi
Oct 3, 2008·Biological Research for Nursing·Martina AntosováTomás Turcan
Mar 19, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikol SulloBruno D'Agostino
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weiguo ChenGurjit K Khurana Hershey
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiro TabataGurjit K Khurana Hershey

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