Is intravenous iron useful for reducing transfusions in surgically treated colorectal cancer patients?

World Journal of Surgery
José Carlos Titos-ArcosEnrique Pellicer-Franco

Abstract

The goal of the present study was to determine whether the intravenous administration of iron in the postoperative period of colon cancer surgical patients suffices to reduce the number of transfusions necessary. The study was designed as a retrospective observational study conducted over a three-year period. A paired case-control design was used to analyze the effect of postoperative iron on patients' blood transfusion needs. Two groups were established (the case group, which received postoperative iron and the control group, which did not) and matched for age (± 3 years), gender, type of operation, tumor stage, and surgical approach. Of 342 patients who underwent operation, 104 paired patients were obtained for inclusion in this study (52 in each group). A second analysis was made to assess the effect of intravenous iron on the evolution of hemoglobin between the first postoperative day and hospital discharge in the subgroup of patients with reduction in hemoglobin, in subjects without preoperative or postoperative transfusions. Finally, a total of 71 patients were paired in two groups: 37 and 31 patients in case and control, respectively. The mean hemoglobin concentration at discharge for the case group was 10 ± 1.1 g/dl, vs...Continue Reading

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Citations

Dec 20, 2012·Expert Review of Anticancer Therapy·Barrie D KeelerAdam E Frampton
Sep 1, 2015·Revista española de anestesiología y reanimación·O Díaz-CambroneroJ Molins-Espinosa
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May 2, 2017·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerKai Zacharowski

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