Is intravenous ketamine effective for postoperative pain management in adults?

Medwave
Camila StuardoFernando Altermatt

Abstract

Ketamine is a N-Metil-D-Aspartate receptor antagonist that has been used as adjuvant in the acute postoperative pain management because of its analgesic properties. However, its role is not clearly determined. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified 19 systematic reviews including 226 randomized trials overall. We extracted data and generated a summary of findings table using the GRADE approach. We concluded intravenous ketamine probably has little or no effect in reducing postoperative pain.

References

Oct 1, 1996·Anesthesia and Analgesia·G R Lauretti, V M Azevedo
Aug 29, 2001·Anesthesia and Analgesia·C MenigauxM Chauvin
Jun 29, 2002·Anesthesia and Analgesia·Akira KudohTomoko Takazawa
Mar 26, 2004·Anesthesia and Analgesia·Rebecca F K KwokWallace K Y Chiu
Feb 19, 2005·European Journal of Anaesthesiology·H KafaliN Kunt
Jun 15, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kathirvel SubramaniamRichard A Steinbrook
Jul 19, 2013·The Korean Journal of Pain·Seung Yeup HanYong Ik Kim

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