Is it time to reconsider how to manage oocytes affected by smooth endoplasmic reticulum aggregates?

Human Reproduction
Lucile FerreuxKhaled Pocate-Cheriet

Abstract

Did the revised Alpha/ESHRE consensus (Vienna, 2017) bring a real answer on managing oocytes with aggregates of smooth endoplasmic reticulum (SERa)? According to the currently available literature, a case by case approach on the time of injecting/inseminating SERa+ oocytes may be not helpful for embryologists making a decision, so we suggest fertilizing both SERa+ and SERa- oocytes and prioritizing embryos derived from SERa- oocytes. In 2011, the Istanbul consensus recommended not to inject/inseminate SER+ oocytes due to adverse foetal outcomes reported in literature. At the end of 2017, a panel of experts reconsidered this recommendation and advised a case by case approach. Hence, with a lack of clear recommendations, in-vitro fertilization practitioners still have heterogeneous attitudes when managing SERa+ oocytes. In this context of controversy, an updated review could be helpful in (i) forming a common language for managing cases of SERa+ oocytes and (ii) offering the most ethical practice and best care for patients seeking infertility treatment or fertility preservation. This review (with a last literature search on 1 June 2018) evaluated the effect of the SER dysmorphism on embryological and neonatal outcomes. Studies we...Continue Reading

References

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Citations

Sep 10, 2020·Molecular Reproduction and Development·Saffet Ozturk
Sep 25, 2020·Reproductive Biomedicine Online·Verna JansGuido de Wert
May 14, 2021·BMC Pregnancy and Childbirth·Hongqin ZhangZhenhua Guo

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